Compare Morphine Sulfate vs. Dilaudid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats severe pain.

Ms Contin (Morphine Sulfate) provides good long-term pain control without the need to take medicine frequently, but watch out for constipation.

3.5/ 5 average rating with 541 reviewsforMorphine Sulfate
Treats moderate to severe pain.

Dilaudid (hydromorphone) is a powerful pain reliever that has significant risks for abuse and overdose.

4.1/ 5 average rating with 51 reviewsforDilaudid
Upsides
  • Provides longer relieve for moderate to severe pain to improve quality of life.
  • Good for chronic pain that requires around-the-clock relief.
  • Might have fewer side effects than other opioid pain relievers.
  • Dilaudid (hydromorphone) works better and faster at relieving pain than morphine.
  • Available in a cheap generic version.
Downsides
  • Doesn't work for as-needed or quick pain relief.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Ms Contin (Morphine Sulfate) if you need.
  • Long term use will likely cause physical dependence.
  • Must be weaned slowly off the medicine after use longer than 2 weeks.
  • Constipation is a common side effect of Dilaudid (hydromorphone) and may require the use of laxatives or stool softeners.
  • Dilaudid (hydromorphone) is fatal when combined with alcohol, muscle relaxants, and other medications that slow breathing.
  • Long-term use of opioids will cause physical dependence.
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Used for
Dosage forms
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Suppository
  • Pill
  • Extended release pill
  • Liquid
  • Suppository
Price
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Reviews
541 reviews so far
55%
saidit'sworth it
43%
saiditworked well
20%
saidit'sa big hassle

Have you used Ms Contin (Morphine Sulfate)?

Leave a review
51 reviews so far
78%
saidit'sworth it
65%
saiditworked well
10%
saidit'sa big hassle

Have you used Dilaudid (hydromorphone)?

Leave a review
Side effects
The Ms Contin (Morphine Sulfate) FDA package insert doesn’t have numbers about how common side effects are.
The Dilaudid (hydromorphone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Death from lack of oxygen to the body (respiratory depression)
    • Current use of medicine that affects liver enzyme CYP 3A4
    • Age 65 or greater
    • Higher dose
    • People with not enough thyroid hormones
    • History of lung problems
  • Death from overdose
    • Children age 18 and younger
  • Death in newborn babies from opioid withdrawal (Neonatal opioid withdrawal syndrome)
    • Long-term use during pregnancy
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Low blood pressure
    • Age 65 years or older
See more detailed risks and warnings
  • Slowed breathing
    • Current use of medicine that affects liver enzyme CYP 3A4
    • Age 65 or greater
    • Higher doses
    • Drinking alcohol
    • Use with benzodiazepines
  • Death from overdose
    • Children age 18 and younger
  • Death of newborn babies from opioid withdrawal
    • Long-term use during pregnancy
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
  • Driving impairment
    • Taking Dilaudid (hydromorphone) with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
See more detailed risks and warnings