Compare Movantik vs. Colace

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Movantik (naloxegol)

Prescription only

Colace (docusate)

Over-the-counter
Relieves constipation caused by opioid pain relievers.

Movantik (naloxegol) is a good option for treating constipation due to the use of opioids. However, it can cause side effects that make you feel like you are going through opioid withdrawal.

Softens your stools.

Colace (docusate) softens the stool, but may not stimulate a bowel movement as quickly as a laxative.

3.6/ 5 average rating with 125 reviewsforColace
Upsides
  • Is a good option if traditional laxatives have not worked for you.
  • Take Movantik (naloxegol) only once a day.
  • Compared to alternatives, this medicine doesn't affect your heart.
  • Safer than laxatives.
  • Available over-the-counter.
  • Safe to use in children as young as 2 years old.
Downsides
  • Side effects of Movantik (naloxegol), including withdrawal and loss of pain control, may be worse in people taking certain opiates, such as methadone.
  • More expensive than traditional laxatives. There is no generic available.
  • Need to take this medicine on an empty stomach or it won't work as well.
  • You may have to take a lower dose of Movantik (naloxegol) if you have kidney problems, which may be less effective or cause more side effects.
  • May take up to 5 days for the full effects to kick in.
  • Intended to be used only as a short-term solution for occasional constipation. Other options such as fiber supplements may be more useful for maintaining regular bowel movements.
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Used for
  • Opioid induced constipation
Dosage forms
  • Pill
  • Pill
  • Enema
  • Liquid
Price
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Reviews
Not enough review data.Leave a review
125 reviews so far
66%
saidit'sworth it
49%
saiditworked well
13%
saidit'sa big hassle

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Side effects
7possible side effects
  • Abdominal pain
    21%
  • Diarrhea
    9%
  • Nausea
    8%
  • Gas
    6%
  • Vomiting
    5%
  • Headache
    4%
  • Excess sweating
    3%
See more detailed side effects
The Colace (docusate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Opioid withdrawal & reduced pain relief
    • Methadone use
  • Severe abdominal pain and/or diarrhea
    • Movantik 25mg
  • Stomach or intestinal holes
    • Crohns disease
    • Peptic ulcer disease
    • Diverticular disease
    • Stomach malignancies
See more detailed risks and warnings
  • Complete or partial blockage of intestines
See more detailed risks and warnings