Compare Mucinex vs. Nyquil Cold And Flu
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Breaks up mucus that causes cough.
Mucinex (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, and it lasts longer than other guaifenesin products.
●●●●●
3.8/ 5 average rating with 902 reviewsforMucinex
Relieves cold and flu symptoms, and helps you sleep.
Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.
●●●●●
3.8/ 5 average rating with 1188 reviewsforNyquil Cold And Flu
Upsides
- Mucinex (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
- Lasts longer than some other products that contain guaifenesin, such as Robitussin, because it's an extended-release form.
- It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
- Available in liquid and tablet forms.
- Mucinex (Guaifenesin) is alcohol- and sugar-free.
- Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
- The cough medicine (dextromethorphan) works well and has very few side effects.
- The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
- The antihistamine (doxylamine) will help you sleep.
Downsides
- Mucinex (Guaifenesin) is more expensive than other medications that treat congestion.
- You need to drink a lot of fluids while taking this medication or it won't work as well.
- Mucinex (Guaifenesin) isn’t useful if you have a dry cough.
- Can cause nausea, headache, and an upset stomach.
- If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
- You shouldn't use it if you have high blood pressure.
- To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Used for
Dosage forms
- Extended release
- Liquid
- Pill
- Liquid
No pricing information available
No pricing information available
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
902 reviews so far
78%
saidit'sworth it
47%
saiditworked well
7%
saidit'sa big hassle
Have you used Mucinex (Guaifenesin)?
Leave a review1188 reviews so far
83%
saidit'sworth it
42%
saiditworked well
7%
saidit'sa big hassle
Have you used Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)?
Leave a reviewSide effects
The Mucinex (Guaifenesin) FDA package insert doesn’t have numbers about how common side effects are.
The Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
- Nausea and vomiting
- Liver damage
- Drinking more than 2 alcoholic beverages a day
- Taking with other Tylenol-containing medicines
- History of liver disease
- Serotonin syndrome
- Using other medications that affect serotonin
- Driving impairment
- Taking with alcohol
- Taking with other medicines that make you less alert
- Antihistamine side effects
- Age 65 years or older
- Glaucoma
- Benign prostatic hypertrophy (BPH)