Compare Myrbetriq vs. Oxybutynin

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Myrbetriq (mirabegron)

Prescription only

Oxytrol (Oxybutynin)

Prescription only
Treats overactive bladder.

Myrbetriq (mirabegron) is a good treatment for overactive bladder with the least chance for dry mouth and constipation, but talk to your doctor if you have high blood pressure.

Treats an overactive bladder.

Oxytrol (Oxybutynin) is a good treatment for overactive bladder, but watch out for side effects such as dry mouth and constipation.

  • Myrbetriq (mirabegron) helps you to have better control over your urination.
  • Myrbetriq (mirabegron) causes less drowsiness and constipation than other medicines for overactive bladder.
  • May be used if you have glaucoma.
  • Myrbetriq (mirabegron) may be safer to use if you are over 65 years old.
  • Oxytrol (Oxybutynin) is effective at treating overactive bladder by lowering the urge to urinate, and helping to better control urination.
  • Available in multiple forms: a patch, gel, extended-release tablet, and tablet.
  • The gel form of Oxytrol (Oxybutynin) is available over the counter without a prescription.
  • Oxytrol (Oxybutynin) patch and gel have fewer side effects than taking the tablet.
  • The tablet is available as a generic.
  • Myrbetriq (mirabegron) might raise your blood pressure.
  • If you have an obstruction in your bladder, Myrbetriq (mirabegron) might make you retain more urine.
  • Myrbetriq (mirabegron) may be very expensive depending on your insurance.
  • Not recommended if you have severe liver or kidney disease.
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
  • Can’t be used if you have uncontrolled narrow-angle glaucoma.
  • Not recommended if you have ulcerative colitis or certain other stomach problems since Oxytrol (Oxybutynin) can slow stomach emptying.
  • Not the best choice if you have GERD (acid reflux), since Oxytrol (Oxybutynin) can irritate your throat and make the acid reflux worse.
  • Has more side effects than newer medicines that treat overactive bladder.
Used for
Dosage forms
  • Extended release
  • Pill
  • Extended release
  • Liquid
  • Cream, gel, or ointment
  • Patch
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Side effects
8possible side effects
  • High blood pressure
  • Common cold symptoms
  • Urinary tract infection
  • Headache
  • Constipation
  • Chest cold infection
  • Joint pain
  • Rapid heart beat
See more detailed side effects
The Oxytrol (Oxybutynin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Increased blood pressure
    • Untreated high blood pressure
  • Urinary retention
    • Bladder outlet obstruction
  • Unusual swelling
See more detailed risks and warnings
  • Unusual tongue swelling
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Heat exhaustion
    • Outside in hot weather
    • Dehydrated
    • Exercising
See more detailed risks and warnings