Compare naproxen vs. Relafen

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Aleve (naproxen)

Prescription or OTC

Relafen (nabumetone)

Prescription only
Relieves pain, fever, and inflammation.

Aleve (naproxen) works well for treating mild to moderate pain or inflammation, and lasts longer than other NSAIDs.

3.9/ 5 average rating with 978 reviewsfornaproxen
Relieves pain and inflammation.

Relafen (nabumetone) works well for relieving pain and inflammation, but may take up to a week to kick in.

Upsides
  • Aleve (naproxen) is good for relieving pain from common conditions like menstrual cramps, toothaches, and arthritis.
  • It lasts longer than other NSAIDS so you don't have to take it as often.
  • Aleve (naproxen) is generally safe to use, cheap, and available over-the-counter.
  • Aleve (naproxen) causes fewer stomach problems than its alternatives.
  • Relafen (nabumetone) is good for relieving pain and inflammation from osteoarthritis and rheumatoid arthritis.
  • Usually taken only once a day, while other NSAIDS need to be taken a few times a day for the same effect.
  • Relafen (nabumetone) causes less stomach upset and overall side effects than other NSAIDs, like ibuprofen and naproxen.
Downsides
  • Aleve (naproxen) needs to be taken with food or millk to lower the chances of upset stomach.
  • Like all NSAIDs, Aleve (naproxen) is as not safe for pregnant women and people who are age 60 or older.
  • It can cause serious complications like stomach bleeding and kidney problems if taken for a long period of time.
  • Like all NSAIDs, Aleve (naproxen) can raise your risk of getting blood clots, heart attack, or stroke.
  • Relafen (nabumetone) does not work as quickly as other NSAIDs.
  • Relafen (nabumetone), like other NSAIDS, is not safe for pregnant women and people who are age 60 or older.
  • Relafen (nabumetone) can cause serious complications including stomach bleeding and kidney problems if taken for a long period of time.
  • The safety and effectiveness of Relafen (nabumetone) for children are not known so they should not take it.
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Used for
Dosage forms
  • Pill
  • Delayed-release pill
  • Extended-release pill
  • Suspension
  • Pill
Price
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Reviews
978 reviews so far
78%
saidit'sworth it
48%
saiditworked well
5%
saidit'sa big hassle

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Side effects
The Aleve (naproxen) FDA package insert doesn’t have numbers about how common side effects are.
3possible side effects
  • Diarrhea
    14%
  • Upset stomach
    13%
  • Stomach pain
    12%
See more detailed side effects
Risks and risk factors
  • Heart attack and stroke
    • History of heart problems
    • Taking the medicine for a long period of time
  • Stomach bleeding
    • History of stomach bleeding or ulcer
    • Age 60 or older
    • Taking aspirin, other NSAIDs, or blood thinners
    • Drinking more than 3 alcoholic beverages a day
    • Smoking
    • Taking the medicine for a long period of time
  • Severe allergic reaction
    • Asthma
    • Nasal polyps
    • Aspirin allergy
    • NSAID allergy
  • Kidney damage
    • Kidney disease
    • Heart failure
    • Taking certain high blood pressure medications
    • Age 60 or older
    • Taking the medicine for a long period of time
  • Harm to fetus
    • Women who want to or can become pregnant
    • Pregnant women
See more detailed risks and warnings
  • Heart attack and stroke
    • History of heart problems
    • Taking Relafen (nabumetone) for a long period of time
  • Stomach bleeding
    • History of stomach bleeding and/or ulcers
    • Age 60 or older
    • Taking aspirin, other NSAIDs, steroids, or blood thinners
    • Drinking alcoholic beverages
    • Smoking
    • Taking the medicine for a long period of time
    • People with poor general health
  • Severe allergic reaction
    • Asthma
    • Nasal polyps
    • Aspirin allergy
    • NSAID allergy
  • Kidney damage
    • Kidney disease
    • Heart failure
    • Liver disease
    • Taking certain high blood pressure medications
    • Age 60 or older
    • Taking the medicine for a long period of time
  • Harm to fetus
    • Pregnant women
    • Women who want to or can become pregnant
  • Heart-related complications
    • Recent heart surgery or heart attack
    • History of high blood pressure
    • History of heart failure
See more detailed risks and warnings