Compare nefazodone vs. Zoloft

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Serzone (nefazodone)

Prescription only

Zoloft (sertraline)

Prescription only
Treats depression.

Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage.

Improves mood and helps you relax.

Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines.

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3.5/ 5 average rating with 1472 reviewsforZoloft
Upsides
  • Serzone (nefazodone) is a good choice to take with other medicines for depression if they haven't worked by themselves.
  • Serzone (nefazodone) is available in generic.
  • One of the more effective and better tolerated antidepressants in its class.
  • Causes less sleepiness than other antidepressants.
  • Available as a generic, which is cheaper.
  • Best choice among antidepressants if you are pregnant.
Downsides
  • While Serzone (nefazodone) is available as a generic, it's not considered a first or second choice medicine for depression because it is more likely to cause liver damage than other similar medicines.
  • Serzone (nefazodone) is usually taken 2 times a day; the first choice medicines are only taken 1 time a day.
  • It can take up to 3 months before you notice the full effects of Serzone (nefazodone).
  • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect.
  • Can cause low sex drive, an inability to orgasm or ejaculate, and minor weight gain (1 to 5 pounds).
  • Is more likely to cause diarrhea compared to other antidepressants.
  • Interacts with lots of other medicines.
  • You may need to try out several different antidepressants before you find the one that works for you.
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Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
Lowest price
$31.97
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Lowest price
$10.99
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Reviews
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1472 reviews so far
59%
saidit'sworth it
41%
saiditworked well
15%
saidit'sa big hassle

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Side effects
42possible side effects
  • Headache
    36%
  • Dry mouth
    25%
  • Sleepiness
    25%
  • Nausea
    22%
  • Dizziness
    17%
  • Constipation
    14%
  • Weakness
    11%
  • Trouble sleeping
    11%
  • Lightheadedness
    10%
  • Indigestion
    9%
  • Blurry vision
    9%
  • Infection
    8%
  • Diarrhea
    8%
  • Confusion
    7%
  • Blind spots in vision
    7%
  • Sore throat
    6%
  • Increased appetite
    5%
  • Changes in blood pressure
    4%
  • Memory problems
    4%
  • Tingling or prickling sensation
    4%
  • Flushing
    4%
  • Flu
    3%
  • Swelling in the arms and legs
    3%
  • Abnormal dreams
    3%
  • Decreased concentration
    3%
  • Increased cough
    3%
  • Chills
    2%
  • Fever
    2%
  • Low blood pressure
    2%
  • Itching
    2%
  • Skin rashes
    2%
  • Nausea and vomiting
    2%
  • Trouble controlling movements
    2%
  • Coordination problems
    2%
  • Slowing of movement or speech
    2%
  • Tremor
    2%
  • Ringing in the ears
    2%
  • Changes in taste
    2%
  • Frequent urination
    2%
  • Urinary tract infection
    2%
  • Problems emptying bladder
    2%
  • Vaginal discharge, itching, and pain
    2%
See more detailed side effects
15possible side effects
  • Nausea
    26%
  • Diarrhea
    18%
  • Dry mouth
    16%
  • Difficulty sleeping
    16%
  • Drowsiness
    13%
  • Dizziness
    12%
  • Tremor
    11%
  • Fatigue
    11%
  • More sweating
    8%
  • Constipation
    8%
  • Ejaculation failure
    7%
  • Upset stomach
    6%
  • Agitation
    6%
  • Loss of appetite
    3%
  • Stomach pain
    2%
See more detailed side effects
Risks and risk factors
  • Higher risk of suicide
    • People under age 24
  • Liver failure
  • Low blood pressure
    • Taking medicine for high blood pressure
  • Possible bipolar disorder
  • Seizures
    • History of seizures
  • Lower heart rate
    • History of heart attack or heart disease
    • Medicines that slow the heartbeat
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Taking other medicines that affect serotonin levels
  • Mania
    • Personal history of bipolar disorder
    • Family history for bipolar disorder
  • Withdrawal
    • Stopping Zoloft (sertraline) suddenly
  • Increased bleeding
    • Taking blood thinners
  • Low sodium levels in the blood
    • Older people
    • Taking diuretic medicines
See more detailed risks and warnings
Learn more about Serzone (nefazodone)
Learn more about Zoloft (sertraline)