Compare nefazodone vs. Zoloft
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage.
Improves mood and helps you relax.
Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines.
3.5/ 5 average rating with 1472 reviewsforZoloft
- Serzone (nefazodone) is a good choice to take with other medicines for depression if they haven't worked by themselves.
- Serzone (nefazodone) is available in generic.
- One of the more effective and better tolerated antidepressants in its class.
- Causes less sleepiness than other antidepressants.
- Available as a generic, which is cheaper.
- Best choice among antidepressants if you are pregnant.
- While Serzone (nefazodone) is available as a generic, it's not considered a first or second choice medicine for depression because it is more likely to cause liver damage than other similar medicines.
- Serzone (nefazodone) is usually taken 2 times a day; the first choice medicines are only taken 1 time a day.
- It can take up to 3 months before you notice the full effects of Serzone (nefazodone).
- Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
- Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect.
- Can cause low sex drive, an inability to orgasm or ejaculate, and minor weight gain (1 to 5 pounds).
- Is more likely to cause diarrhea compared to other antidepressants.
- Interacts with lots of other medicines.
- You may need to try out several different antidepressants before you find the one that works for you.
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42possible side effects
- Dry mouth25%
- Trouble sleeping11%
- Blurry vision9%
- Blind spots in vision7%
- Sore throat6%
- Increased appetite5%
- Changes in blood pressure4%
- Memory problems4%
- Tingling or prickling sensation4%
- Swelling in the arms and legs3%
- Abnormal dreams3%
- Decreased concentration3%
- Increased cough3%
- Low blood pressure2%
- Skin rashes2%
- Nausea and vomiting2%
- Trouble controlling movements2%
- Coordination problems2%
- Slowing of movement or speech2%
- Ringing in the ears2%
- Changes in taste2%
- Frequent urination2%
- Urinary tract infection2%
- Problems emptying bladder2%
- Vaginal discharge, itching, and pain2%
15possible side effects
- Dry mouth16%
- Difficulty sleeping16%
- More sweating8%
- Ejaculation failure7%
- Upset stomach6%
- Loss of appetite3%
- Stomach pain2%
Risks and risk factors
- Higher risk of suicide
- People under age 24
- Liver failure
- Low blood pressure
- Taking medicine for high blood pressure
- Possible bipolar disorder
- History of seizures
- Lower heart rate
- History of heart attack or heart disease
- Medicines that slow the heartbeat
- Suicidal thoughts or behavior
- Age 24 years or younger
- Serotonin syndrome
- Taking other medicines that affect serotonin levels
- Personal history of bipolar disorder
- Family history for bipolar disorder
- Stopping Zoloft (sertraline) suddenly
- Increased bleeding
- Taking blood thinners
- Low sodium levels in the blood
- Older people
- Taking diuretic medicines