Compare Nesina vs. Actos

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Nesina (alogliptin)

Prescription only

Actos (pioglitazone)

Prescription only
Lowers your blood sugar.

Nesina (alogliptin) is a good add-on treatment for diabetes if your blood sugars are still not controlled, but it doesn't work as well as insulin.

Lowers blood sugar.

Actos (pioglitazone) can improve blood sugar control but is not a top choice since it has a lot of side effects.

3.1/ 5 average rating with 175 reviewsforActos
Upsides
  • Less likely to cause weight gain or low blood sugar compared to other anti-diabetic medicines.
  • Pill may be preferred by some patients over injection.
  • Improves sugar control and lowers A1c levels by around 1%.
  • Easily taken by mouth as a once a day pill.
  • Prevents the harmful effects of high sugar levels on your organs.
  • Rarely causes low blood sugar.
  • Lower the risk of heart attack or stroke.
Downsides
  • Does not lower your A1c (average blood sugar over time) as much as insulin.
  • Available as an expensive, branded product only.
  • Has more troublesome side-effects than other anti-diabetic pills.
  • May take several weeks to lower blood sugar.
  • Can cause weight gain.
  • People with heart failure or history of bladder cancer shouldn't use this medicine.
  • Some people might get fluid accumulation (edema), from minor ankle swelling to fluid in lungs that makes it hard to breathe.
  • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
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Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
Not enough review data.Leave a review
175 reviews so far
42%
saidit'sworth it
30%
saiditworked well
21%
saidit'sa big hassle

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Side effects
The Nesina (alogliptin) FDA package insert doesn’t have numbers about how common side effects are.
11possible side effects
  • Low blood sugar
    27%
  • Swelling
    27%
  • Colds and flu
    13%
  • Headache
    9%
  • Heart failure
    8%
  • Sinus infection
    6%
  • Back pain
    6%
  • Pain in arms and legs
    6%
  • Muscle pain
    5%
  • Sore throat
    5%
  • Chest pain
    5%
See more detailed side effects
Risks and risk factors
  • Pancreatitis (inflammation of the pancreas)
    • History of pancreatitis
    • High blood triglyceride levels
    • Gallstones (stones in gallbladder)
  • Liver damage
  • Serious allergic reactions
  • Low blood sugar (hypoglycemia)
    • Taking medicines for diabetes
  • Severe joint pain and swelling
See more detailed risks and warnings
  • Heart failure
    • Heart failure
  • Fluid buildup
  • Liver damage
    • Current liver problems
  • Bladder cancer
    • History of bladder cancer
  • Bone fracture
    • Women
  • Low blood sugar
See more detailed risks and warnings