Compare Nesina vs. Afrezza

Head-to-head comparisons of medication uses, side effects, ratings, and more.

ADVERTISEMENT
Lowers your blood sugar.

alogliptin is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.

Controls mealtime blood sugar.

Afrezza (insulin) is effective at controlling blood sugar, but you can't use it if you've had lung problems or smoke.

Upsides
  • Oral blood sugar-lowering medicine.
  • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
  • Rarely causes low blood sugar.
  • Patients taking alogliptin had less cold symptoms than patients taking Januvia.
  • Afrezza (insulin) is as effective as other mealtime insulin products.
  • Starts working faster and stays in your body for a shorter time than other mealtime insulin products, so you're less likely to have severely low blood sugar.
  • If you don't like needles, Afrezza (insulin) is a good alternative since you inhale it.
  • Safe to use in people 65 or older.
  • Talk to your doctor or pharmacist about ways to lower your copay, such as coupons.
Downsides
  • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
  • Likely expensive since there's no generic version available.
  • Some people might get frequent throat infections or nasal congestion.
  • Not recommended if you're a smoker or if you've smoked in the last 6 months.
  • Afrezza (insulin) only comes in 3 different strengths, so it can be inconvenient if you need a lot of insulin.
  • Not recommended in children under 18.
  • If you're pregnant, you'll need to talk to your doctor before you start Afrezza (insulin).
  • There is no generic available, and may not be covered right away by Medicare or other insurances.
ADVERTISEMENT
Used for
  • Diabetes mellitus type 2
Dosage forms
  • Pill
  • Inhalation powder
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
Not enough review data.Leave a review
Not enough review data.Leave a review
Side effects
The Nesina (Alogliptin) FDA package insert doesn’t have numbers about how common side effects are.
6possible side effects
  • Cough
    28%
  • Throat pain or irritation
    6%
  • Headache
    5%
  • Worsening lung function test
    3%
  • Airway inflammation
    3%
  • Urinary tract infection
    2%
See more detailed side effects
Risks and risk factors
  • Pancreatitis
  • Liver damage
See more detailed risks and warnings
  • Low blood sugar
    • Changes in diet and exercise
    • Drinking alcohol
    • Taking other medications for diabetes
    • Over age 65
    • Liver or kidney problems
  • Breathing problems
    • Asthma
    • Chronic Obstructive Pulmonary Disease (COPD)
    • Other long term lung problems
  • Low blood potassium levels
    • Taking laxatives
    • Taking medications that increase urination
  • Worsening lung function
    • Smoking
    • Second-hand smoke
    • Indoor and outdoor pollution
    • Work-related fume and chemical exposure
  • Fluid buildup
    • Taking Avandia or Actos
  • Too much acid in the blood
    • Type 1 diabetes
    • Long periods of fasting
    • Alchohol abuse
    • History of pancreatitis
See more detailed risks and warnings