Compare Nesina vs. Glucotrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Nesina (alogliptin)

Prescription only

Glucotrol (glipizide)

Prescription only
Lowers your blood sugar.

Nesina (alogliptin) is a good add-on treatment for diabetes if your blood sugars are still not controlled, but it doesn't work as well as insulin.

Lowers blood sugar.

Glucotrol (glipizide) is an effective medicine for lowering blood sugar, but it can cause your blood sugar level to be too low so you must always carry some form of sugar with you that can be readily used.

3.2/ 5 average rating with 332 reviewsforGlucotrol
Upsides
  • Less likely to cause weight gain or low blood sugar compared to other anti-diabetic medicines.
  • Pill may be preferred by some patients over injection.
  • Lowers A1c levels by 1-2%.
  • Glucotrol (glipizide) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Okay to use by people with kidney problems.
  • Available as a generic form and is relatively cheap.
Downsides
  • Does not lower your A1c (average blood sugar over time) as much as insulin.
  • Available as an expensive, branded product only.
  • Has more troublesome side-effects than other anti-diabetic pills.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • While taking Glucotrol (glipizide), your blood sugars should be checked 2 to 5 times a week, but less often once you are on a stable dose.
  • Can cause mild weight gain of 2-3lb.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
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Used for
Dosage forms
  • Pill
  • Pill
  • Extended release pill
Price
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Reviews
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332 reviews so far
50%
saidit'sworth it
32%
saiditworked well
19%
saidit'sa big hassle

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Side effects
The Nesina (alogliptin) FDA package insert doesn’t have numbers about how common side effects are.
9possible side effects
  • Dizziness
    7%
  • Diarrhea
    5%
  • Nervousness
    4%
  • Tremor
    4%
  • Low blood sugar
    3%
  • Constipation
    3%
  • Passing gas
    3%
  • Nausea
    3%
  • Headache
    2%
See more detailed side effects
Risks and risk factors
  • Pancreatitis (inflammation of the pancreas)
    • History of pancreatitis
    • High blood triglyceride levels
    • Gallstones (stones in gallbladder)
  • Liver damage
  • Serious allergic reactions
  • Low blood sugar (hypoglycemia)
    • Taking medicines for diabetes
  • Severe joint pain and swelling
See more detailed risks and warnings
  • Serious heart problems
  • Low blood sugar
    • Skipping meals or having inconsistent meal times
    • Drinking alcohol
    • Using other blood sugar-lowering medicine
    • People age 60 or older
    • Those with kidney and/or liver problems
  • Severe allergic reaction
    • History of allergy to sulfa-containing medicine
  • Kidney and liver disease
    • Those with kidney and/or liver disease
  • Breakdown of red blood cells
    • People with G6PD deficiency
See more detailed risks and warnings