Compare Nesina vs. glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Nesina (alogliptin)

Prescription only

Diabeta (glyburide)

Prescription only
Lowers your blood sugar.

Nesina (alogliptin) is a good add-on treatment for diabetes if your blood sugars are still not controlled, but it doesn't work as well as insulin.

Lowers blood sugar.

Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.

3.3/ 5 average rating with 110 reviewsforglyburide
Upsides
  • Less likely to cause weight gain or low blood sugar compared to other anti-diabetic medicines.
  • Pill may be preferred by some patients over injection.
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
Downsides
  • Does not lower your A1c (average blood sugar over time) as much as insulin.
  • Available as an expensive, branded product only.
  • Has more troublesome side-effects than other anti-diabetic pills.
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
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Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
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110 reviews so far
45%
saidit'sworth it
34%
saiditworked well
21%
saidit'sa big hassle

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Side effects
The Nesina (alogliptin) FDA package insert doesn’t have numbers about how common side effects are.
2possible side effects
  • Nausea and heartburn
    2%
  • Skin allergies
    2%
See more detailed side effects
Risks and risk factors
  • Pancreatitis (inflammation of the pancreas)
    • History of pancreatitis
    • High blood triglyceride levels
    • Gallstones (stones in gallbladder)
  • Liver damage
  • Serious allergic reactions
  • Low blood sugar (hypoglycemia)
    • Taking medicines for diabetes
  • Severe joint pain and swelling
See more detailed risks and warnings
  • Low blood sugar
    • Over age 65
    • Kidney problems
    • Use of other blood sugar lowering medicines
    • Alcohol
    • Intense physical activity
  • Severe allergic reactions
    • History of sulfa allergies
See more detailed risks and warnings