Compare Neupro vs. carbidopa / levodopa / entacapone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Helps with movement disorders due to Parkinson's or restless legs syndrome.

Neupro (rotigotine) is an effective treatment for Parkinson's disease or restless legs syndrome, but can cause troublesome side-effects related to impulse control.

Treats Parkinson's disease.

Stalevo (carbidopa / levodopa / entacapone) is a good choice for Parkinson's disease, especially when carbidopa/levodopa starts losing its effect.

Upsides
  • Can use regardless of any pre-existing kidney or liver problems.
  • Single, daily patch provides all-day control of movement disorders.
  • Good alternative for those with difficulty swalloing pills.
  • Good option for elderly because of its lower risk for confusion or mental disturbances compared to other medicines like it.
  • It combines three medicines into one pill so you don't have to take so many pills daily.
  • Stalevo (carbidopa / levodopa / entacapone) is available as a generic.
Downsides
  • Available as brand product only and may be expensive if not covered by your insurance.
  • Patch's adhesive may irritate the skin at site of application.
  • Heat exposure can affect stability of the patch.
  • Neupro (rotigotine) can lead to withdrawal symptoms if the medication is stopped suddenly.
  • You would first start by taking Stalevo (carbidopa / levodopa / entacapone) as two different pills, carbidopa/levodopa and entacapone, before you get switched over to Stalevo (carbidopa / levodopa / entacapone).
  • It's less customizable since there are only a few fixed combinations available.
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Used for
Dosage forms
  • Patch
  • Pill
Price
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Reviews
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Side effects
22possible side effects
  • Nausea
    48%
  • Skin irritation
    32%
  • Dizziness
    22%
  • Vomiting
    20%
  • Sleepiness
    19%
  • Insomnia
    14%
  • Increased sweating
    11%
  • Anorexia
    9%
  • Fatigue
    6%
  • Visual disturbances
    5%
  • Constipation
    5%
  • Redness
    5%
  • Abnormal dreams
    3%
  • Abnormal electrocardiogram reading
    3%
  • Difficulty with maintaining balance
    3%
  • Upset stomach
    3%
  • Ringing in the ears
    3%
  • Hallucinations
    3%
  • Muscle spasms
    3%
  • Numbness of the hands and feet
    3%
  • Swelling of the hands and feet
    3%
  • White blood cells in urine
    3%
See more detailed side effects
20possible side effects
  • Difficulty controlling movements
    25%
  • Muscle spasm
    10%
  • Changes in urine color
    10%
  • Discolored urine
    10%
  • Muscle rigidity
    9%
  • Dizziness
    8%
  • Abdominal pain
    8%
  • Fatigue
    6%
  • Constipation
    6%
  • Back pain
    5%
  • Vomiting
    4%
  • Dry mouth
    3%
  • Shortness of breath
    3%
  • Bruising
    3%
  • Increased sweating
    2%
  • Anxiety
    2%
  • Sleepiness
    2%
  • Indigestion
    2%
  • Flatulence
    2%
  • Weakness
    2%
See more detailed side effects
Risks and risk factors
  • Sulfite sensitivity
  • Driving impairment
    • Taking other medicines that make you sleepy
    • Sleep disorders
  • Hallucinations and unusual changes in thought
    • Psychotic disorders
  • Low blood pressure
    • Taking blood pressure medicines
  • Impulse control problems
  • Heat exposure
See more detailed risks and warnings
  • Difficulty controlling movements
  • Diarrhea
  • Muscle damage
  • Changes in blood pressure and falls
  • Stomach bleeding
    • History of stomach ulcers
See more detailed risks and warnings