Compare Niaspan vs. Crestor

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Niaspan (Niacin)

Prescription only

Crestor (rosuvastatin)

Prescription only
Lowers cholesterol.

Niaspan (Niacin) lowers triglycerides, but isn't as good as statins for improving cholesterol levels.

3.2/ 5 average rating with 380 reviewsforNiaspan
Lowers cholesterol.

Crestor (rosuvastatin) is one of the most effective statins to improve cholesterol. It's also available as a generic.

3.7/ 5 average rating with 751 reviewsforCrestor
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Good for lowering triglycerides (fats).
  • It's a good first choice medicine for lowering cholesterol levels when diet and exercise aren't enough.
  • Slows down the buildup of fatty deposits in your blood vessels, otherwise known as a hardening of the arteries.
  • In clinical studies, Crestor (rosuvastatin) has the strongest effect on lowering "bad" cholesterol compared to other statins.
  • Can lower your risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • Available as a generic drug.
  • By itself, Niaspan (Niacin) isn't as effective as statins for improving cholesterol levels.
  • It can cause flushing and stomach pain or discomfort.
  • You need to take it before bedtime with a low-fat snack.
  • If you miss doses often, you may need to re-start taking the medicine more regularly at a lower dose.
  • You're more likely to have side effects if you're a female, are 65 years or older, drink alcohol every day, or take more than one medicine for cholesterol.
  • People with liver disease, kidney disease, or diabetes are also more likely to have side effects from Crestor (rosuvastatin).
  • Crestor (rosuvastatin) isn't safe to use if you're pregnant since it can hurt the fetus.
Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
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380 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Niaspan (Niacin)?

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751 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Crestor (rosuvastatin)?

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Side effects
6possible side effects
  • Flushing
  • Itching
  • Diarrhea
  • Nausea
  • Rash
  • Cough increased
See more detailed side effects
The Crestor (rosuvastatin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Muscle pain
    • Taking Niaspan (Niacin) with statins
  • Liver damage
    • Heavy alcohol use
    • Past history of liver disease
  • High blood sugar
    • Diabetes
  • Low platelets
    • Taking Niaspan (Niacin) with anticoagulants
  • Gout
    • Gout
See more detailed risks and warnings
  • Elevated INR
    • Taking Coumadin (warfarin)
  • Muscle pain
    • Age 65 or older
    • Taking higher doses of Crestor (rosuvastatin)
  • Increased blood sugars
    • Diabetes
  • Liver damage
    • Heavy alcohol use
    • Prior history of chronic liver disease
  • Birth defects
    • Pregnancy
See more detailed risks and warnings