Compare Nifedipine vs. Zestoretic

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lowers blood pressure and controls heart rate.

Nifedipine works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding grapefruit. You can't miss doses, and you might get persistent swelling.

2.8/ 5 average rating with 26 reviewsforNifedipine
Lowers blood pressure.

Lisinopril/hydrochlorothiazide is a good 2-in-1 blood pressure-lowering medicine that protects kidney function.

3.4/ 5 average rating with 294 reviewsforZestoretic
Upsides
  • A first-choice blood pressure treatment for many people.
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • You can take it alone or with other medicines to help lower blood pressure.
  • Lowers the risk of heart attack and stroke.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Treats certain abnormal heart rhythms.
  • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
  • The two drugs in Lisinopril/hydrochlorothiazide work together to lower blood pressure, remove extra water from your body, and lower your risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
Downsides
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Nifedipine than men.
  • You can't miss doses. Stopping Nifedipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Not a good medication for you if you love grapefruit. It can make Nifedipine have a stronger effect on your blood pressure.
  • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Makes you urinate more often.
  • Doesn't work as well in people with severe kidney problems.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
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Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
Price
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Reviews
26 reviews so far
42%
saidit'sworth it
31%
saiditworked well
46%
saidit'sa big hassle

Have you used Procardia (Nifedipine)?

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294 reviews so far
51%
saidit'sworth it
40%
saiditworked well
17%
saidit'sa big hassle

Have you used Zestoretic (Lisinopril / Hydrochlorothiazide)?

Leave a review
Side effects
11possible side effects
  • Dizziness, lightheadedness, giddiness
    27%
  • Flushing
    25%
  • Headache
    23%
  • Weakness
    12%
  • Nausea, heartburn
    11%
  • Muscle cramps, tremor
    8%
  • Peripheral edema
    7%
  • Nervousness, mood changes
    7%
  • Palpitation
    7%
  • Dyspnea, cough, wheezing
    6%
  • Nasal congestion, sore throat
    6%
See more detailed side effects
11possible side effects
  • Dizziness
    8%
  • Headache
    5%
  • Cough
    4%
  • Fatigue
    4%
  • Orthostatic Effects
    3%
  • Diarrhea
    3%
  • Nausea
    2%
  • Upper Respiratory Infection
    2%
  • Muscle Cramps
    2%
  • Asthenia
    2%
  • Paresthesia
    2%
See more detailed side effects
Risks and risk factors
  • Intestinal blockage
    • Taking anti-inflammatories, acid reducers in the stomach, anticholinergics, laxatives, levothyroxine
    • History of intestinal surgery
  • Chest pain
    • Taking beta-blockers
    • Severe coronary artery disease.
  • Liver damage/jaundice
    • History of cirrhosis
  • Low blood pressure
  • Congestive heart failure
    • History of tight aortic stenosis
    • Taking beta-blockers
  • Heart attack or increased chest pain
    • Obstructive coronary artery disease
See more detailed risks and warnings
  • Harm to fetus
    • Women of childbearing age
  • Unusual tongue swelling
    • African descent
  • Severe allergic reactions while on dialysis
    • People requiring high flux dialysis
  • Acute kidney failure
    • History of kidney disease
  • Heart problems due to high potassium
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
  • Cough
See more detailed risks and warnings