Compare Nitrofurantoin vs. Bactrim

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats urinary tract infections.

Macrobid (Nitrofurantoin) works best in young, otherwise healthy females. It shouldn't be used by children, the elderly, or people with kidney problems.

Kills bacteria.

Bactrim (sulfamethoxazole / trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn.

3.6/ 5 average rating with 473 reviewsforBactrim
  • Macrobid (Nitrofurantoin) works well to treat urinary tract infections.
  • Young and otherwise healthy females have the best results when taking Macrobid (Nitrofurantoin).
  • It's not too common, but you can get a test done that'll show if Macrobid (Nitrofurantoin) will work for you.
  • Widely available as a generic product and in a variety of formulations (tablet, capsule, suspension).
  • Works well to treat many types of bacterial infections
  • Shouldn't be used for a long period of time.
  • Can't be used in children under 12 years old.
  • Interacts with drugs like probenecid and sulfinpyrazone.
  • Can't be used if you have kidney problems or don't urinate often (the medication could build up and cause toxicity).
  • Makes you sensitive to the sun.
  • Can upset your stomach
  • Drink plenty of water or fluids to avoid harming your kidneys
  • May cause birth defects
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Liquid
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473 reviews so far
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saiditworked well
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Have you used Bactrim (sulfamethoxazole / trimethoprim)?

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Side effects
3possible side effects
  • Nausea
  • Headache
  • Gas
See more detailed side effects
The Bactrim (sulfamethoxazole / trimethoprim) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Birth defects
    • Pregnant women
    • Newborn babies
  • Kidney damage
    • History of kidney disease
  • Liver damage
    • History of liver disease
  • Diarrhea from a superinfection
    • Long antibiotic treatment period
See more detailed risks and warnings
  • Diarrhea
  • Sunburn
  • Rash
  • Harm to fetus
  • Lower kidney function
    • Elderly
    • Taking other medicines that lower kidney function
See more detailed risks and warnings