Compare Nitrofurantoin vs. Bactrim

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats urinary tract infections.

Macrobid (Nitrofurantoin) works best in young, otherwise healthy females. It shouldn't be used by children, the elderly, or people with kidney problems.

Kills bacteria.

Bactrim (sulfamethoxazole / trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn.

3.6/ 5 average rating with 473 reviewsforBactrim
Upsides
  • Macrobid (Nitrofurantoin) works well to treat urinary tract infections.
  • Young and otherwise healthy females have the best results when taking Macrobid (Nitrofurantoin).
  • It's not too common, but you can get a test done that'll show if Macrobid (Nitrofurantoin) will work for you.
  • Widely available as a generic product and in a variety of formulations (tablet, capsule, suspension).
  • Works well to treat many types of bacterial infections
Downsides
  • Shouldn't be used for a long period of time.
  • Can't be used in children under 12 years old.
  • Interacts with drugs like probenecid and sulfinpyrazone.
  • Can't be used if you have kidney problems or don't urinate often (the medication could build up and cause toxicity).
  • Makes you sensitive to the sun.
  • Can upset your stomach
  • Drink plenty of water or fluids to avoid harming your kidneys
  • May cause birth defects
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Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Liquid
Price
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Reviews
Not enough review data.Leave a review
473 reviews so far
59%
saidit'sworth it
49%
saiditworked well
22%
saidit'sa big hassle

Have you used Bactrim (sulfamethoxazole / trimethoprim)?

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Side effects
3possible side effects
  • Nausea
    8%
  • Headache
    6%
  • Gas
    2%
See more detailed side effects
The Bactrim (sulfamethoxazole / trimethoprim) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Birth defects
    • Pregnant women
    • Newborn babies
  • Kidney damage
    • History of kidney disease
  • Liver damage
    • History of liver disease
  • Diarrhea from a superinfection
    • Long antibiotic treatment period
See more detailed risks and warnings
  • Diarrhea
  • Sunburn
  • Rash
  • Harm to fetus
  • Lower kidney function
    • Elderly
    • Taking other medicines that lower kidney function
See more detailed risks and warnings