Compare Norco vs. methadone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats moderate to moderately severe pain.

Norco (hydrocodone / acetaminophen) is a good option to treat pain when over-the-counter medicines haven't worked, but it can lead to dependence and tolerance if taken for a long time.

3.7/ 5 average rating with 1194 reviewsforNorco
Treats severe pain or drug dependence.

Methadose (methadone) is a cheap and effective treatment for severe chronic pain, but has serious risks for fatal overdose and drug dependence.

Upsides
  • Norco (hydrocodone / acetaminophen) has two medicines to treat moderate to moderately severe pain. The combination is more effective than either drug alone.
  • Norco (hydrocodone / acetaminophen) is more potent than many over-the-counter options.
  • You can take this with or without food.
  • This medicine also comes as a liquid if you have trouble swallowing.
  • Norco (hydrocodone / acetaminophen) is available as a generic.
  • Available as a cheap, generic version.
  • One of the stronger opioid medicines for treatment of severe pain.
  • Can also be used to treat opioid dependence as part of a complete recovery program.
Downsides
  • Constipation, dizziness, drowsiness, and nausea can commonly occur.
  • Since Norco (hydrocodone / acetaminophen) is a controlled medication, it cannot be refilled or transferred to another pharmacy.
  • Long-term use can cause dependence and tolerance.
  • Too much Norco (hydrocodone / acetaminophen) can damage the liver.
  • Not effective in treating all kinds of pain.
  • Methadose (methadone) can cause slowed breathing, coma, and death from overdose, especially if mixed with alcohol, sleeping pills, or muscle relaxants.
  • Constipation is a common side effect of Methadose (methadone) and you might need laxatives or stool softeners.
  • Not a good option for short-term pain relief.
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Used for
  • Moderate to severe pain
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Dissolving tablet
  • Liquid
Price
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Reviews
1194 reviews so far
67%
saidit'sworth it
44%
saiditworked well
13%
saidit'sa big hassle

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Side effects
The Norco (hydrocodone / acetaminophen) FDA package insert doesn’t have numbers about how common side effects are.
The Methadose (methadone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Liver failure
    • Current liver disease
    • Taking Norco (hydrocodone / acetaminophen) with alcohol
    • Taking other medicines containing acetaminophen
  • Slowed breathing
    • Age 65 or greater
    • High dosages
    • History of lung problems
    • Taking other painkillers or sedatives
  • Severe allergic reactions
    • Taking more than the prescribed dose
    • Long-term use
    • History of substance abuse
    • Younger age
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
    • Younger age
  • Constipation
    • Age 65 or greater
    • Long-term use of opioids
    • Taking drugs that cause constipation
  • Confusion and drowsiness
    • Drinking alcohol
    • Age 65 years or older
See more detailed risks and warnings
  • Death from lack of oxygen to the body (respiratory depression)
    • Start of treatment
    • Age 65 or greater
    • Dose changes and higher doses
  • Heart problems (arrhythmia)
    • History of cardiovascular disease
  • Driving impairment
    • Taking Methadose (methadone) with alcohol
    • Taking other medicines that make you less alert
  • Death from overdose
    • Children age 18 and younger
    • Taking more than prescribed dose
    • Mixing with alcohol or drugs that interact with Methadose (methadone)
  • Abuse, tolerance, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse or mental illness
See more detailed risks and warnings