Compare Norco vs. oxycodone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats moderate to moderately severe pain.

Norco (hydrocodone / acetaminophen) is a good option to treat pain when over-the-counter medicines haven't worked, but it can lead to dependence and tolerance if taken for a long time.

3.7/ 5 average rating with 1194 reviewsforNorco
Treats moderate to severe pain.

Oxycontin (oxycodone) treats moderate to severe pain, but can be habit-forming, especially if used long-term.

3.8/ 5 average rating with 1241 reviewsforoxycodone
Upsides
  • Norco (hydrocodone / acetaminophen) has two medicines to treat moderate to moderately severe pain. The combination is more effective than either drug alone.
  • Norco (hydrocodone / acetaminophen) is more potent than many over-the-counter options.
  • You can take this with or without food.
  • This medicine also comes as a liquid if you have trouble swallowing.
  • Norco (hydrocodone / acetaminophen) is available as a generic.
  • Oxycontin (oxycodone) is available in a tamper-resistant form to lessen the risk of abuse.
  • Liquid form is available if you have trouble swallowing.
  • Available in a generic version.
  • The extended-release pill provides around-the-clock pain relief with convenient once or twice daily dosing.
Downsides
  • Constipation, dizziness, drowsiness, and nausea can commonly occur.
  • Since Norco (hydrocodone / acetaminophen) is a controlled medication, it cannot be refilled or transferred to another pharmacy.
  • Long-term use can cause dependence and tolerance.
  • Too much Norco (hydrocodone / acetaminophen) can damage the liver.
  • Not effective in treating all kinds of pain.
  • Constipation, dizziness, drowsiness, and nausea commonly occur.
  • Long-term use can cause dependence and tolerance.
  • Not effective in treating all kinds of pain.
  • It’s not safe to start taking extended-release pills if you've never taken an opioid medicine before.
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Used for
  • Moderate to severe pain
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Extended-release pill
  • Liquid
Price
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Reviews
1194 reviews so far
67%
saidit'sworth it
44%
saiditworked well
13%
saidit'sa big hassle

Have you used Norco (hydrocodone / acetaminophen)?

Leave a review
1241 reviews so far
66%
saidit'sworth it
50%
saiditworked well
19%
saidit'sa big hassle

Have you used Oxycontin (oxycodone)?

Leave a review
Side effects
The Norco (hydrocodone / acetaminophen) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Constipation
    23%
  • Nausea
    23%
  • Sleepiness
    23%
  • Dizziness
    13%
  • Itchiness
    13%
  • Vomiting
    12%
  • Headache
    7%
  • Dry mouth
    6%
  • Weakness
    6%
  • Sweating
    5%
See more detailed side effects
Risks and risk factors
  • Liver failure
    • Current liver disease
    • Taking Norco (hydrocodone / acetaminophen) with alcohol
    • Taking other medicines containing acetaminophen
  • Slowed breathing
    • Age 65 or greater
    • High dosages
    • History of lung problems
    • Taking other painkillers or sedatives
  • Severe allergic reactions
    • Taking more than the prescribed dose
    • Long-term use
    • History of substance abuse
    • Younger age
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
    • Younger age
  • Constipation
    • Age 65 or greater
    • Long-term use of opioids
    • Taking drugs that cause constipation
  • Confusion and drowsiness
    • Drinking alcohol
    • Age 65 years or older
See more detailed risks and warnings
  • Slowed breathing
    • Age 65 or greater
    • High dosages
    • After dose change
    • History of lung problems
    • Taking other painkillers or sedatives
  • Harm to newborn babies
    • Long-term use during pregnancy
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
    • Younger age
  • Interactions with other medicines
    • Taking medicines that also cause sleepiness or slowed breathing
  • Confusion and drowsiness
    • Age 65 or greater
    • High dosages
    • Taking other painkillers or sedatives
  • Death from overdose
    • Taking alcohol, other opioids, or benzodiazepines
    • Children age 18 and younger
See more detailed risks and warnings