Compare Novolog vs. Glucotrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Novolog (insulin aspart)

Prescription only

Glucotrol (glipizide)

Prescription only
Lowers blood sugar.

Novolog (insulin aspart) is a fast-acting insulin that provides meal-time blood sugar control. For long-term control, you'll need to take Novolog (insulin aspart) with other medicines to keep your overall blood sugar down.

3.5/ 5 average rating with 177 reviewsforNovolog
Lowers blood sugar.

Glucotrol (glipizide) is an effective medicine for lowering blood sugar, but it can cause your blood sugar level to be too low so you must always carry some form of sugar with you that can be readily used.

3.2/ 5 average rating with 332 reviewsforGlucotrol
Upsides
  • When used correctly, this medication will l lower blood sugar every time you use it and prevent the harmful, long-term effects of high sugar levels on your organs and blood vessels.
  • You can easily change the dose of Novolog (insulin aspart) to fit your individual needs.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Can use Novolog (insulin aspart) even if you have liver or kidney problems, unlike many other blood sugar-lowering medicines.
  • Lowers A1c levels by 1-2%.
  • Glucotrol (glipizide) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Okay to use by people with kidney problems.
  • Available as a generic form and is relatively cheap.
Downsides
  • Have to take insulin by injection.
  • Might have to check your blood sugar multiple times a day, usually before each meal.
  • Novolog (insulin aspart) is likely to cause moderate weight gain.
  • Higher risk of low blood sugar episodes compared to other kinds of diabetes medications.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • While taking Glucotrol (glipizide), your blood sugars should be checked 2 to 5 times a week, but less often once you are on a stable dose.
  • Can cause mild weight gain of 2-3lb.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
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Used for
Dosage forms
  • Injection
  • Pill
  • Extended release pill
Price
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Reviews
177 reviews so far
58%
saidit'sworth it
46%
saiditworked well
19%
saidit'sa big hassle

Have you used Novolog (insulin aspart)?

Leave a review
332 reviews so far
50%
saidit'sworth it
32%
saiditworked well
19%
saidit'sa big hassle

Have you used Glucotrol (glipizide)?

Leave a review
Side effects
The Novolog (insulin aspart) FDA package insert doesn’t have numbers about how common side effects are.
9possible side effects
  • Dizziness
    7%
  • Diarrhea
    5%
  • Nervousness
    4%
  • Tremor
    4%
  • Low blood sugar
    3%
  • Constipation
    3%
  • Passing gas
    3%
  • Nausea
    3%
  • Headache
    2%
See more detailed side effects
Risks and risk factors
  • Life-threatening low blood sugar (Hypoglycemia)
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
    • Changes in meal pattern or exercise
    • Kidney problems
    • Liver problems
  • Complications due to low potassium
    • Use of medications that lower potassium
    • Current imbalance of electrolytes
  • Severe allergic reactions
    • Allergy to insulin
See more detailed risks and warnings
  • Serious heart problems
  • Low blood sugar
    • Skipping meals or having inconsistent meal times
    • Drinking alcohol
    • Using other blood sugar-lowering medicine
    • People age 60 or older
    • Those with kidney and/or liver problems
  • Severe allergic reaction
    • History of allergy to sulfa-containing medicine
  • Kidney and liver disease
    • Those with kidney and/or liver disease
  • Breakdown of red blood cells
    • People with G6PD deficiency
See more detailed risks and warnings