Compare Noxafil vs. Ambisome

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats and prevents fungal infections.

Noxafil (posaconazole) works against many different fungal infections, but may require close follow-up for potential side effects and drug interactions.

Treats fungal infections.

Effective treatment for severe and otherwise, deadly fungal infections.

Upsides
  • Noxafil (posaconazole) works against more types of fungal infections than other medications like it.
  • Available in liquid form if you have difficulty swallowing pills.
  • This is a potentially life-saving medication for serious fungal infections.
  • May cause less side effects and harm to your kidneys compared to the conventional formulation of the drug and Abelcet.
  • Your doctor may be able to give you medicines to prevent or manage any reactions you may have to Ambisome (amphotericin B liposome).
Downsides
  • Available as brand version only so may be more expensive than other medications like it.
  • Noxafil (posaconazole) has many drug interactions.
  • The pill and liquid forms are not readily interchangeable without your doctor's help.
  • Can only be given as an injection that runs over 1 to 2 hours.
  • Can only be given in a hospital or by trained home health care professional.
  • The entire treatment can range from 1 to 12 weeks, depending on the severity of your infection.
  • Has a lot of side effects like fever, chills, nausea, vomitting, and diarrhea. Your doctor may order regular blood tests to monitor your labs.
  • Your body may have an allergic reaction to the drug or the way it is administered.
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Used for
  • Prevention of fungal infection.
  • Treatment of fungal infection in the mouth or throat
Dosage forms
  • Extended release pill
  • Liquid
  • Injection
Price
Lowest price
$5841.74
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Side effects
16possible side effects
  • Diarrhea
    10%
  • Nausea
    9%
  • Headache
    8%
  • Vomiting
    7%
  • Fever
    6%
  • Abdominal pain
    5%
  • Low white blood cells
    4%
  • Fatigue
    3%
  • Herpes simplex
    3%
  • Lung infection
    3%
  • Coughing
    3%
  • Rash
    3%
  • Anorexia
    2%
  • Weakness
    2%
  • Low red blood cells
    2%
  • Increased sweating
    2%
See more detailed side effects
44possible side effects
  • Chills
    48%
  • Low potassium
    43%
  • Nausea
    40%
  • Vomiting
    32%
  • Diarrhea
    30%
  • Rash
    25%
  • HIgh glucose
    23%
  • Shortness of breath
    23%
  • Liver labs (alkaline phosphatase) increased
    22%
  • Abnormal kidney function tests (creatinine)
    22%
  • Abnormal kidney function tests (blood urea nitrogen)
    21%
  • Abdominal pain
    20%
  • Low magnesium
    20%
  • Headache
    20%
  • Blood product transfusion reaction
    18%
  • Abnormal liver function (bilirubinemia)
    18%
  • Low calcium
    18%
  • Cough increased
    18%
  • Lung disorder
    18%
  • Insomnia
    17%
  • Abnormal liver enzymes (ALT)
    15%
  • Swelling of the hands and feet
    15%
  • Sudden nose bleeds
    15%
  • Pain
    14%
  • Life-threatening infection
    14%
  • Low blood pressure
    14%
  • Fluid retention
    14%
  • Anxiety
    14%
  • Blood in urine
    14%
  • Weakness
    13%
  • Fast heart rate
    13%
  • Fluid in the lungs
    13%
  • Back pain
    12%
  • Chest pain
    12%
  • Low fluid volume
    12%
  • Infection
    11%
  • Confusion
    11%
  • Runny nose
    11%
  • Itching
    11%
  • Bleeding in the stomach
    9%
  • High blood pressure
    8%
  • Low oxygen in the lungs
    8%
  • Sweating
    7%
  • High sodium
    4%
See more detailed side effects
Risks and risk factors
  • Abnormal heartbeat
    • QT prolongation
    • Arrhythmia
    • Drugs that cause prolonged QT interval
    • Abnormal electrolytes
  • Liver problems
    • Blood disorder
    • Liver disease
  • Kidney problems
    • Kidney problems
    • Kidney disease
  • Drug toxicity
See more detailed risks and warnings
  • Severe allergic reaction
  • Injection related side effects
  • Kidney injury
    • Preexisting kidney disease
    • Dehydration
  • Low magnesium and potassium
    • Preexisting low magnesium or potassium
  • Changes in blood pressure
See more detailed risks and warnings