Compare Noxafil vs. Itraconazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Noxafil (posaconazole)

Prescription only

Sporanox (itraconazole)

Prescription only
Treats and prevents fungal infections.

Noxafil (posaconazole) works against many different fungal infections, but may require close follow-up for potential side effects and drug interactions.

Treats fungal infections.

Sporanox (itraconazole) is effective oral medication that treats many different kinds of fungal infections. However, it has the potential to interact with a lot of other medications and has a few serious but rare side effects.

Upsides
  • Noxafil (posaconazole) works against more types of fungal infections than other medications like it.
  • Available in liquid form if you have difficulty swallowing pills.
  • Sporanox (itraconazole) is effective in treating infections caused by many different types of fungi.
  • Available as a generic in the capsule form.
  • Sporanox (itraconazole) can be used by people who have kidney problems.
Downsides
  • Available as brand version only so may be more expensive than other medications like it.
  • Noxafil (posaconazole) has many drug interactions.
  • The pill and liquid forms are not readily interchangeable without your doctor's help.
  • The liquid solution is especially likely to cause stomach upset like nausea and diarrhea.
  • Sporanox (itraconazole) is not a good choice for simple fungal infections (like nail infections) in people who have congestive heart failure because it can cause high blood pressure and swelling of the limbs.
  • Sporanox (itraconazole) isn't absorbed in the same way by everyone. You'll likely need to get lab tests done to check on its levels in the blood.
  • Sporanox (itraconazole) can cause serious side effects like allergic reactions, liver toxicity, nerve pain, or hearing loss.
  • Sporanox (itraconazole) has a lot of drug interactions. Let your doctor or pharmacist know about all of the medications you're taking.
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Used for
  • Prevention of fungal infection.
  • Treatment of fungal infection in the mouth or throat
  • Salvage therapy for invasive aspergillosis
  • Blastomycosis
  • Oropharyngeal and esophageal candidiasis
  • Histoplasmosis
  • Onychomycosis
  • Vulvovaginal candidiasis in HIV-infected patients
  • Coccidioidal meningitis in HIV-infected patients
  • Coccidioidal pneumonia in HIV-infected patients
  • Cryptococcosis in HIV-infected patients
  • Disseminated microsporidiosis in HIV-infected patients
  • Penicilliosis in HIV-infected patients
Dosage forms
  • Extended release pill
  • Liquid
  • Pill
  • Liquid
Price
Lowest price
$5841.73
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Reviews
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Side effects
16possible side effects
  • Diarrhea
    10%
  • Nausea
    9%
  • Headache
    8%
  • Vomiting
    7%
  • Fever
    6%
  • Abdominal pain
    5%
  • Low white blood cells
    4%
  • Fatigue
    3%
  • Herpes simplex
    3%
  • Lung infection
    3%
  • Coughing
    3%
  • Rash
    3%
  • Anorexia
    2%
  • Weakness
    2%
  • Low red blood cells
    2%
  • Increased sweating
    2%
See more detailed side effects
14possible side effects
  • Nausea
    11%
  • Rash
    9%
  • Vomiting
    5%
  • Swelling due to fluid retention
    4%
  • Headache
    4%
  • Diarrhea
    3%
  • Tiredness
    3%
  • Fever
    3%
  • Itching
    3%
  • High blood pressure
    3%
  • Lowered liver function
    3%
  • Abdominal pain
    2%
  • Dizziness
    2%
  • Low potassium
    2%
See more detailed side effects
Risks and risk factors
  • Abnormal heartbeat
    • QT prolongation
    • Arrhythmia
    • Drugs that cause prolonged QT interval
    • Abnormal electrolytes
  • Liver problems
    • Blood disorder
    • Liver disease
  • Kidney problems
    • Kidney problems
    • Kidney disease
  • Drug toxicity
See more detailed risks and warnings
  • Congestive Heart Failure
    • History of congestive heart failure
  • Drug interactions
  • Liver toxicity
  • Irregular heartbeat
    • Taking other medications that can produce an irregular heartbeat
  • Do not switch between the capsules or liquid forms
See more detailed risks and warnings