Compare Nucala vs. Singulair

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Nucala (mepolizumab)

Prescription only

Singulair (montelukast)

Prescription only
Helps control severe asthma.

Nucala (mepolizumab) is an effective add-on medication for reducing severe asthma symptoms and improving breathing, but is very expensive.

Makes it easier to breathe.

Singulair (montelukast) has fewer side effects but doesn't work as well as some inhaled medications for asthma and allergies.

3.7/ 5 average rating with 557 reviewsforSingulair
Upsides
  • You only need to take Nucala (mepolizumab) once every 4 weeks.
  • There are no dosing adjustments for people with kidney or liver problems.
  • Nucala (mepolizumab) can be used by children over 12 years old.
  • Although not a first-line treatment, Singulair (montelukast) can effectively help children and adults with their asthma and allergies.
  • You only need to take it once a day.
  • Available as chewable tablets or granules that you can mix with food.
  • Singulair (montelukast) has fewer side effects than inhaled medications.
Downsides
  • Nucala (mepolizumab) only comes as an injection, so you have to be comfortable with needles.
  • You will need have Nucala (mepolizumab) administered at a clinic or doctor's office.
  • Nucala (mepolizumab) can cause a severe, life-threatening allergic reaction which doesn't happen with other non-injectable asthma medications.
  • Nucala (mepolizumab) has no generic available and can be expensive.
  • Even as a generic, Singulair (montelukast) is still expensive.
  • May not be a good choice if you have a history of mental conditions.
  • Singulair (montelukast) can't be used as a rescue inhaler if you get an asthma attack.
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Used for
Dosage forms
  • Injection
  • Pill
  • Chewable tablet
  • Granule
Price
No pricing information available
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Reviews
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557 reviews so far
66%
saidit'sworth it
47%
saiditworked well
14%
saidit'sa big hassle

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Side effects
10possible side effects
  • Headache
    19%
  • Injection site reaction
    8%
  • Back pain
    5%
  • Fatigue
    5%
  • Flu
    3%
  • Urinary tract infection
    3%
  • Upper stomach pain
    3%
  • Itchiness
    3%
  • Eczema
    3%
  • Muscle spasms
    3%
See more detailed side effects
13possible side effects
  • Headache
    18%
  • Flu
    4%
  • Stomach pain
    3%
  • Cough
    3%
  • Lack of energy
    2%
  • Fever
    2%
  • Upset stomach
    2%
  • Dental pain
    2%
  • Stomach infection
    2%
  • Dizziness
    2%
  • Stuffy nose
    2%
  • Rash
    2%
  • Abnormal liver function tests
    2%
See more detailed side effects
Risks and risk factors
  • Allergic reactions
  • Infections
    • Helminth infection
See more detailed risks and warnings
  • Asthma attacks
    • Exercise-induced asthma
    • Other environmental triggers
  • Aggression and agitation
  • Blood disorder
    • Recent treatment with corticosteroid medicine
    • Lowering dose of corticosteroid medicine
  • Phenylketonuria
    • Phenylketonuria (PKU)
See more detailed risks and warnings