Compare Nucynta vs. oxycodone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Nucynta (tapentadol)

Prescription only

Oxycontin (oxycodone)

Prescription only
Treats moderate to severe pain.

Nucynta (tapentadol) is a good option to treat pain and may be more tolerable than other opioid pain medications.

Treats moderate to severe pain.

Oxycontin (oxycodone) treats moderate to severe pain, but can be habit-forming, especially if used long-term.

3.8/ 5 average rating with 1241 reviewsforoxycodone
Upsides
  • In studies, Nucynta (tapentadol) was effective in treating certain kinds of pain.
  • May not cause as much nausea and constipation as other opioid pain medicines.
  • You can take Nucynta (tapentadol) with or without food; it makes no difference.
  • Oxycontin (oxycodone) is available in a tamper-resistant form to lessen the risk of abuse.
  • Liquid form is available if you have trouble swallowing.
  • Available in a generic version.
  • The extended-release pill provides around-the-clock pain relief with convenient once or twice daily dosing.
Downsides
  • If you're taking the immediate release form of Nucynta (tapentadol), you may need to take it up to 6 times a day to relieve your pain.
  • You may not be able to drive or operate heavy machinery, until you know how Nucynta (tapentadol) affects you.
  • Nucynta (tapentadol) may increase the chance of seizures.
  • Nucynta (tapentadol) is more expensive than most other opioid pain medications. A generic option of Nucynta (tapentadol) is not available.
  • Constipation, dizziness, drowsiness, and nausea commonly occur.
  • Long-term use can cause dependence and tolerance.
  • Not effective in treating all kinds of pain.
  • It’s not safe to start taking extended-release pills if you've never taken an opioid medicine before.
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Used for
Dosage forms
  • Pill
  • Pill
  • Extended-release pill
  • Liquid
Price
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Reviews
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1241 reviews so far
66%
saidit'sworth it
50%
saiditworked well
19%
saidit'sa big hassle

Have you used Oxycontin (oxycodone)?

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Side effects
11possible side effects
  • Nausea
    30%
  • Dizziness
    24%
  • Vomiting
    18%
  • Sleepiness
    15%
  • Constipation
    8%
  • Itchy skin
    5%
  • Dry mouth
    4%
  • Exessive sweating
    3%
  • Indigestion
    2%
  • Decreased appetite
    2%
  • Trouble sleeping
    2%
See more detailed side effects
10possible side effects
  • Constipation
    23%
  • Nausea
    23%
  • Sleepiness
    23%
  • Dizziness
    13%
  • Itchiness
    13%
  • Vomiting
    12%
  • Headache
    7%
  • Dry mouth
    6%
  • Weakness
    6%
  • Sweating
    5%
See more detailed side effects
Risks and risk factors
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
    • Younger age
    • Depression
    • Alcoholism
  • Life-threatening lack of oxygen to the body
    • Taking more than the prescribed dose
    • Taking with alcohol or other opioid drugs
    • Within 24 to 72 hours of first starting Nucynta (tapentadol) or after a dose increase
  • Death in newborn babies from opioid withdrawal
    • Long-term use during pregnancy
  • Accidental poisoning
  • Alcohol use
    • Alcohol
  • Using other sedatives at the same time
    • Taking benzodiazepines or sedatives
See more detailed risks and warnings
  • Slowed breathing
    • Age 65 or greater
    • High dosages
    • After dose change
    • History of lung problems
    • Taking other painkillers or sedatives
  • Harm to newborn babies
    • Long-term use during pregnancy
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
    • Younger age
  • Interactions with other medicines
    • Taking medicines that also cause sleepiness or slowed breathing
  • Confusion and drowsiness
    • Age 65 or greater
    • High dosages
    • Taking other painkillers or sedatives
  • Death from overdose
    • Taking alcohol, other opioids, or benzodiazepines
    • Children age 18 and younger
See more detailed risks and warnings