Compare Odefsey vs. Descovy

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats HIV infection

Odefsey (emtricitabine / rilpivirine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections. It's similar to Complera, but contains a newer HIV drug which has shown to cause less harmful effects on your kidneys and bones.

Works with other medicines to treat HIV.

Descovy (emtricitabine / tenofovir alafenamide) is a first choice combination tablet that is used with other medications to treat HIV and is safe for your kidneys and bones.

Upsides
  • Odefsey (emtricitabine / rilpivirine / tenofovir) combines three medications into one tablet, so it's easy to take.
  • Odefsey (emtricitabine / rilpivirine / tenofovir) is currently the smallest combination HIV tablet available.
  • Odefsey (emtricitabine / rilpivirine / tenofovir) works similar to Complera, but is less likely to cause harmful side effects on your kidneys and bones.
  • Odefsey (emtricitabine / rilpivirine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
  • Compared to Truvada (a similar drug formulation), Descovy (emtricitabine / tenofovir alafenamide) is safe for your kidneys and bones.
  • Take only once daily, with or without food.
  • Children 12 years or older can take Descovy (emtricitabine / tenofovir alafenamide).
Downsides
  • Odefsey (emtricitabine / rilpivirine / tenofovir) has to be taken with a light meal.
  • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need an acid reducer, try taking an antacid like calcium carbonate either 2 hours before or 4 hours after Odefsey (emtricitabine / rilpivirine / tenofovir). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Odefsey (emtricitabine / rilpivirine / tenofovir).
  • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
  • Can cause abnormal heart rhythm.
  • Might worsen hepatitis B infections if you suddenly stop taking Descovy (emtricitabine / tenofovir alafenamide).
  • Descovy (emtricitabine / tenofovir alafenamide) is only approved to treat HIV, not to stop you from getting it.
  • Since Descovy (emtricitabine / tenofovir alafenamide) is not a generic, it may be expensive.
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Dosage forms
  • Pill
  • Pill
Price
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$2670.55
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$1672.61
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Reviews
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Side effects
8possible side effects
  • Headache
    19%
  • Depression
    19%
  • Somnolence
    14%
  • Nausea
    11%
  • Dizziness
    8%
  • Abdominal pain
    8%
  • Vomiting
    6%
  • Rash
    6%
See more detailed side effects
1possible side effects
  • Nausea
    10%
See more detailed side effects
Risks and risk factors
  • Lactic acidosis | Enlarged, fatty liver
    • Liver disease
    • Women
    • Obesity
  • Worsening hepatitis B infection
    • Hepatitis B Virus infection
  • Mood and behavior changes
    • History of mental health problems
  • Bone loss/osteoporosis
    • History of bone fractures
    • Osteoporosis
  • Kidney damage
    • History of kidney damage
    • Taking other medicines that can harm the kidneys
  • Allergic reactions
    • Prior severe allergic reaction to Odefsey (emtricitabine / rilpivirine / tenofovir) or any of its individual drug components.
See more detailed risks and warnings
  • Sudden worsening of Hepatitis B virus (HBV)
    • Hepatitis B virus
  • Lactic acidosis and enlarged, fatty liver
    • Liver disease
    • Obesity
  • Kidney damage
    • History of kidney damage
    • Using other drugs known to harm kidneys
  • Weakened bones
    • History of bone fractures
    • Osteoporosis
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV medication
See more detailed risks and warnings