Compare Oleptro vs. Zoloft
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Improves mood and helps you sleep.
Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
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3.6/ 5 average rating with 59 reviewsforOleptro
Improves mood and helps you relax.
Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines.
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3.5/ 5 average rating with 1472 reviewsforZoloft
Upsides
- Commonly used in lower doses to help treat sleep problems (insomnia).
- Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
- Fewer sexual side effects than many other antidepressants.
- Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
- Comes as a generic medication and is cheaper than many other sleep aides.
- Six out of ten people who use an antidepressant for the first time find that it works for them.
- One of the more effective and better tolerated antidepressants in its class.
- Causes less sleepiness than other antidepressants.
- Available as a generic, which is cheaper.
- Best choice among antidepressants if you are pregnant.
Downsides
- Not as effective as other medications for depression.
- More sedating than other antidepressants.
- Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
- Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
- The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
- Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect.
- Can cause low sex drive, an inability to orgasm or ejaculate, and minor weight gain (1 to 5 pounds).
- Is more likely to cause diarrhea compared to other antidepressants.
- Interacts with lots of other medicines.
- You may need to try out several different antidepressants before you find the one that works for you.
Used for
- Depression
- Obsessive-compulsive disorder (OCD)
- Panic disorder
- Post-traumatic stress disorder (PTSD)
- Premenstrual dysphoric disorder (PMDD)
- Social anxiety disorder
- Anxiety
- Bulimia nervosa
Dosage forms
- Pill
- Extended release
- Pill
- Liquid
Price
Lowest price
$4.00
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$6.52
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Reviews
59 reviews so far
73%
saidit'sworth it
49%
saiditworked well
24%
saidit'sa big hassle
Have you used Oleptro (Trazodone)?
Leave a review1472 reviews so far
59%
saidit'sworth it
41%
saiditworked well
15%
saidit'sa big hassle
Have you used Zoloft (sertraline)?
Leave a reviewSide effects
29possible side effects
- Somnolence/Sedation46%
- Drowsiness41%
- Dry Mouth34%
- Headache33%
- Dizziness/Lightheadedness28%
- Dry mouth25%
- Dizziness25%
- Nausea21%
- Blurred Vision15%
- Fatigue15%
- Nausea/Vomiting13%
- Diarrhea9%
- Constipation8%
- Skin Condition/Edema7%
- Weight Loss6%
- Nasal/Sinus Congestion6%
- Abdominal/Gastric Disorder6%
- Syncope5%
- Musculoskeletal Aches/Pains5%
- Tremors5%
- Nightmares/Vivid Dreams5%
- Weight Gain5%
- Back pain5%
- Vision blurred5%
- Sexual dysfunction5%
- Hypotension4%
- Incoordination2%
- Ejaculation disorders2%
- Decreased libido2%
15possible side effects
- Nausea26%
- Diarrhea18%
- Dry mouth16%
- Difficulty sleeping16%
- Drowsiness13%
- Dizziness12%
- Tremor11%
- Fatigue11%
- More sweating8%
- Constipation8%
- Ejaculation failure7%
- Upset stomach6%
- Agitation6%
- Loss of appetite3%
- Stomach pain2%
Risks and risk factors
- Suicidal thoughts or behavior
- Age 24 years or younger
- Seizures
- History of seizures
- Alcoholism
- Eating disorder
- Higher dose
- Drug interactions
- Painful erection
- Low blood pressure
- Age 65 years or older
- Driving impairment
- Alcohol
- Taking other medicines that make you less alert
- Suicidal thoughts or behavior
- Age 24 years or younger
- Serotonin syndrome
- Taking other medicines that affect serotonin levels
- Mania
- Personal history of bipolar disorder
- Family history for bipolar disorder
- Withdrawal
- Stopping Zoloft (sertraline) suddenly
- Increased bleeding
- Taking blood thinners
- Low sodium levels in the blood
- Older people
- Taking diuretic medicines