Compare olopatadine vs. Allegra

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Pataday (olopatadine)

Prescription only

Allegra (fexofenadine)

Relieves itchy eyes due to allergies.

Pataday (olopatadine) is an effective treatment for itchy eyes due to allergies, but it doesn't treat eye irritation caused by infections or contact lens wear.

Treats allergy symptoms.

Allegra (fexofenadine) relieves allergy symptoms without making you feel drowsy.

3.9/ 5 average rating with 24 reviewsforAllegra
  • Starts working in less than 30 minutes.
  • Safe to use in children age 2 or older.
  • Pataday (olopatadine) is available in a once daily formulation.
  • Most people experience little side effects since the medicine works in your eyes and doesn't affect the rest of your body.
  • Safe to be used together with other oral medicines that also treat allergies.
  • Allegra (fexofenadine) is effective at reducing symptoms for seasonal allergies and chronic hives without significant drowsiness, unlike Benadryl.
  • Approved for kids aged 6 months or older.
  • Allegra (fexofenadine) comes in many forms, like tablet, liquid, and quick-dissolving tablet.
  • Available as a prescription only.
  • Pataday (olopatadine) comes in a generic form, but is still relatively expensive compared to its alternatives.
  • Doesn't help relieve itch related to infections or contact lens wear.
  • Good control of hand and eye movements is needed in order to get the medicine into the eyes successfully.
  • Allegra (fexofenadine)'s effectiveness can wear off over time.
  • The dose needs to be adjusted for people with kidney problems.
Used for
Dosage forms
  • Eye drops
  • Pill
  • Dissolving tablet
  • Liquid
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24 reviews so far
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Side effects
The Pataday (olopatadine) FDA package insert doesn’t have numbers about how common side effects are.
4possible side effects
  • Dizziness
  • Back Pain
  • Stomach discomfort
  • Pain in hands/feet
See more detailed side effects
Risks and risk factors
  • For external use only
  • Not to be used with contact lenses
  • Keeping the applicator clean
See more detailed risks and warnings
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Brain damage from too much phenylalanine
    • History of phenylketonuria (PKU)
See more detailed risks and warnings