Compare olopatadine vs. Astepro

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Pataday (olopatadine)

Prescription only

Astepro (azelastine)

Prescription only
Relieves itchy eyes due to allergies.

Pataday (olopatadine) is an effective treatment for itchy eyes due to allergies, but it doesn't treat eye irritation caused by infections or contact lens wear.

Relieves nasal allergy symptoms.

Astepro (azelastine) is an antihistamine nasal spray that can help with allergy or nasal symptoms.

  • Starts working in less than 30 minutes.
  • Safe to use in children age 2 or older.
  • Pataday (olopatadine) is available in a once daily formulation.
  • Most people experience little side effects since the medicine works in your eyes and doesn't affect the rest of your body.
  • Safe to be used together with other oral medicines that also treat allergies.
  • Astepro (azelastine) is good for relieving nasal symptoms during allergy season.
  • Since Astepro (azelastine) goes in the nose, it's unlikely you'll get side effects anywhere else in your body.
  • Astepro (azelastine) works faster than steroid nasal sprays and can be used as needed.
  • People usually tolerate Astepro (azelastine) well since there are few side effects.
  • Available as a prescription only.
  • Pataday (olopatadine) comes in a generic form, but is still relatively expensive compared to its alternatives.
  • Doesn't help relieve itch related to infections or contact lens wear.
  • Good control of hand and eye movements is needed in order to get the medicine into the eyes successfully.
  • Astepro (azelastine) has 200 sprays, but no counter to help keep track of sprays.
  • It can cause a bitter taste in your mouth.
Used for
  • Allergy-related itchy eyes
  • Allergies
Dosage forms
  • Eye drops
  • Nasal spray
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Side effects
The Pataday (olopatadine) FDA package insert doesn’t have numbers about how common side effects are.
5possible side effects
  • Bitter Taste
  • Nose discomfort
  • Nosebleeds
  • Headache
  • Fatigue
See more detailed side effects
Risks and risk factors
  • For external use only
  • Not to be used with contact lenses
  • Keeping the applicator clean
See more detailed risks and warnings
  • Difficulty concentrating
    • Taking with alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings