Compare Olysio vs. Copegus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats hepatitis C infection.

Olysio (simeprevir) is effective in treating chronic hepatitis C, but it must be used with other antiviral medicines.

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Upsides
  • Most people who take Olysio (simeprevir) together with other antiviral medicines have good results, with no signs of virus found in their blood three months later.
  • Unlike some other hepatitis C medications, you can take Olysio (simeprevir) even if you are taking an acid reflux medication.
  • Can take Olysio (simeprevir) for a shorter amount of time than other hepatitis C medications.
  • Has less side effects than some hepatitis C medications.
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Downsides
  • There's no generic available, so it can be very expensive.
  • Olysio (simeprevir) should not be used alone, it must be used together with other antiviral medicines.
  • There are many interactions between Olysio (simeprevir) and other drugs and herbal supplements. Talk to your doctor or pharmacist before starting any new medications.
  • Olysio (simeprevir) can cause a rash if you're out in the sun, so you'll have to use sunblock or wear protective clothing.
  • Olysio (simeprevir) only works with one specific type of hepatitis C, unlike others that treat all 6 types.
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Used for
  • Hematopoietic stem cell transplant - Respiratory syncytial virus infection Hepatitis C
  • Chronic
  • Combination therapy in interferon alfa-naive patients with compensated liver disease - HIV infection Hepatitis C
  • Chronic
  • With compensated liver disease Respiratory syncytial virus infection
  • Herpes simplex Influenza Viral hemorrhagic fever
Dosage forms
  • Pill
  • Pill
  • Liquid
  • Inhaler
Price
No pricing information available
Lowest price
$24720.03
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Reviews
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Side effects
5possible side effects
  • Rash
    28%
  • Itchy skin
    22%
  • Nausea
    22%
  • Muscle pain
    16%
  • Trouble breathing
    12%
See more detailed side effects
The Copegus (Ribavirin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Hepatitis B reactivation
    • History of hepatitis B infection
  • Slow heart rate
    • Amiodarone
    • Beta blockers
    • Heart disease
    • Liver disease
  • Drug interactions
    • Rifampin
    • St. John's wort
  • Ribavirin combination treatment
    • Taking ribavirin with Olysio (simeprevir)
  • Skin problems
    • Taking Olysio (simeprevir) in combination with rivabirin and peg-interferon alfa
See more detailed risks and warnings
No information currently available
Learn more about Olysio (simeprevir)
Learn more about Copegus (Ribavirin)