Compare omeprazole vs. Aciphex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Prilosec (omeprazole)

Prescription or OTC

Aciphex (rabeprazole)

Prescription only
Treats heartburn and excess release of stomach acid.

Prilosec (omeprazole) gives you long-lasting heartburn relief but has some risks if used long term.

4.0/ 5 average rating with 1167 reviewsforomeprazole
Treats heartburn and ulcers.

Aciphex (rabeprazole) is good for treating heartburn and ulcers, but should not be used long-term.

Upsides
  • Prilosec (omeprazole) lasts longer (up to 72 hours) than other classes of acid reducers (like Zantac, Pepcid, or Tums).
  • Only take once or twice daily.
  • Can take together with a quick-acting antacid (like Maalox or Tums) for quick relief.
  • Generic and over-the-counter options available.
  • Safe to use in children ages 1 or older.
  • Aciphex (rabeprazole) works better than over-the-counter medications that have not relieved your acid reflux.
  • The delayed-release pill provides relief over 24 hours.
  • Aciphex (rabeprazole) can be taken with or without food.
  • The capsule can be safely used by children as young as 1 year old.
Downsides
  • Takes up to an hour to start noticing the effects of Prilosec (omeprazole).
  • Prilosec (omeprazole) can interact with other drugs. Let your doctor and pharmacist know what medications you're taking before starting Prilosec (omeprazole).
  • Long-term use of Prilosec (omeprazole) can put you at risk for many health issues such as osteoporosis, low magnesium or vitamin B12 levels, and rebound acid secretion (where your body starts to create more acid than before after stoping Prilosec (omeprazole)).
  • Using Aciphex (rabeprazole) for a long time can can weaken your bones or increase your risk for infectious diarrhea.
  • Lowers magnesium and vitamin B12 in your body so you may need to take supplements.
  • Aciphex (rabeprazole) interferes with how many medications work.
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Used for
Dosage forms
  • Pill
  • Powder
  • Delayed release pill
Price
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Reviews
1167 reviews so far
80%
saidit'sworth it
59%
saiditworked well
8%
saidit'sa big hassle

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Side effects
11possible side effects
  • Headache
    7%
  • Abdominal pain
    5%
  • Nausea
    4%
  • Diarrhea
    4%
  • Vomiting
    3%
  • Flatulence
    3%
  • Acid regurgitation
    2%
  • Upper respiratory infection
    2%
  • Constipation
    2%
  • Dizziness
    2%
  • Rash
    2%
See more detailed side effects
5possible side effects
  • Headache
    10%
  • Diarrhea
    5%
  • Nausea
    5%
  • Vomiting
    4%
  • Abdominal pain
    4%
See more detailed side effects
Risks and risk factors
  • Risk of cancer
  • Lupus
    • History of cutaneous or systemic lupus erythematosus
  • Severe diarrhea associated with C.difficile infection
    • Being hospitalized
    • Antibiotic use
  • Bone fractures
    • Osteoporosis
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Use of other medications that weaken bones
  • Low Vitamin B12 and Magnesium
    • Taking water pills (Magnesium)
    • Women (Vitamin B12)
    • Over the age of 30 (Vitamin B12)
  • Kidney damage
See more detailed risks and warnings
  • Stomach cancer
  • Kidney inflammation
  • Severe diarrhea
    • Being hospitalized
    • Antibiotic use
  • Bone fractures
    • High dose Aciphex (rabeprazole)
    • Taking Aciphex (rabeprazole) for longer than one year
    • Low bone mineral density
    • Age 50 years or older
    • Alcohol
    • Smoking
    • Taking steroids or anti-seizure medicines
  • Low levels of magnesium and vitamin B12
  • Lupus
See more detailed risks and warnings