Compare omeprazole vs. Maalox

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats heartburn and excess release of stomach acid.

Prilosec (omeprazole) gives you long-lasting heartburn relief but has some risks if used long term.

4.0/ 5 average rating with 1167 reviewsforomeprazole
Relieves heartburn and indigestion.

Maalox (aluminum / magnesium / simethicone) gives quick relief for heartburn, gas, and bloating, but it may not be as effective or last as long as other antacids.

3.4/ 5 average rating with 213 reviewsforMaalox
  • Prilosec (omeprazole) lasts longer (up to 72 hours) than other classes of acid reducers (like Zantac, Pepcid, or Tums).
  • Only take once or twice daily.
  • Can take together with a quick-acting antacid (like Maalox or Tums) for quick relief.
  • Generic and over-the-counter options available.
  • Safe to use in children ages 1 or older.
  • Works quickly.
  • Inexpensive and available over-the-counter.
  • Is one of the first choice medications for heartburn relief if you are pregnant.
  • Takes up to an hour to start noticing the effects of Prilosec (omeprazole).
  • Prilosec (omeprazole) can interact with other drugs. Let your doctor and pharmacist know what medications you're taking before starting Prilosec (omeprazole).
  • Long-term use of Prilosec (omeprazole) can put you at risk for many health issues such as osteoporosis, low magnesium or vitamin B12 levels, and rebound acid secretion (where your body starts to create more acid than before after stoping Prilosec (omeprazole)).
  • Doesn't last very long. Talk to your doctor or pharmacist if you need longer lasting relief.
  • Is not a good option if you have frequent symptoms (more than 2 times a week). Talk to your doctor or pharmacist about stronger medications.
Used for
Dosage forms
  • Pill
  • Powder
  • Chewable tablet
  • Liquid
No pricing information available
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1167 reviews so far
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Have you used Prilosec (omeprazole)?

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213 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Maalox (aluminum / magnesium / simethicone)?

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Side effects
11possible side effects
  • Headache
  • Abdominal pain
  • Nausea
  • Diarrhea
  • Vomiting
  • Flatulence
  • Acid regurgitation
  • Upper respiratory infection
  • Constipation
  • Dizziness
  • Rash
See more detailed side effects
The Maalox (aluminum / magnesium / simethicone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Risk of cancer
  • Lupus
    • History of cutaneous or systemic lupus erythematosus
  • Severe diarrhea associated with C.difficile infection
    • Being hospitalized
    • Antibiotic use
  • Bone fractures
    • Osteoporosis
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Use of other medications that weaken bones
  • Low Vitamin B12 and Magnesium
    • Taking water pills (Magnesium)
    • Women (Vitamin B12)
    • Over the age of 30 (Vitamin B12)
  • Kidney damage
See more detailed risks and warnings
  • Long term use
  • Aluminum and magnesium overdose
    • Kidney problems
    • Taking more than the recommended daily maximum
  • Drug interactions
See more detailed risks and warnings