Compare Onglyza vs. glyburide
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Lowers blood sugar.
Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.
Lowers blood sugar.
Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.
●●●●●
3.3/ 5 average rating with 110 reviewsforglyburide
Upsides
- DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
- Does not cause weight gain.
- May be a good option for those with bad liver function.
- Does not cause hypoglycemia (low blood sugar) when taken by itself.
- Available as an oral tablet.
- Lowers your A1c (average blood sugar over time) up to 2%.
- Available in generic version.
- Available in single pill combination with other anti-diabetic medicines.
Downsides
- Typically not first-choice treatment for diabetes.
- Only lowers A1C (average blood sugar over time) by ~0.5%.
- Risk for heart failure has not been seen in other medicines that work just like it.
- May be more expensive than other anti-diabetic medicines.
- More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
- You will have to check your blood sugar often when you first start taking it.
- Can cause weight gain (about 2 to 3 pounds).
- Not ideal for elderly or those with poor kidney function.
- May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
Used for
Dosage forms
- Pill
- Pill
Price
Lowest price
$432.40
Find instant savings near youLowest price
$12.65
Find instant savings near youWant to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
Not enough review data.Leave a review
110 reviews so far
45%
saidit'sworth it
34%
saiditworked well
21%
saidit'sa big hassle
Have you used Diabeta (glyburide)?
Leave a reviewSide effects
The Onglyza (saxagliptin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
- inflammation of the pancreas
- Alcoholism
- Elevated triglycerides
- History of pancreatitis
- Gallstones
- Heart failure
- History of heart failure
- Bad kidney function
- Low blood sugar (hypoglycemia)
- Alcohol
- Unexpected changes in diet
- Changes in amount of exercise
- Taking other anti-diabetic medications
- Severe allergic reactions
- Severe joint pain
- Fluid-filled blisters on the skin (bullous pemphigoid)
- Low blood sugar
- Over age 65
- Kidney problems
- Use of other blood sugar lowering medicines
- Alcohol
- Intense physical activity
- Severe allergic reactions
- History of sulfa allergies