Compare Onglyza vs. Humalog

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Onglyza (saxagliptin)

Prescription only

Humalog (insulin lispro)

Prescription only
Lowers blood sugar.

Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.

Lowers blood sugar.

Humalog (insulin lispro) is a fast-acting insulin that controls blood sugar around meal times.

3.7/ 5 average rating with 280 reviewsforHumalog
Upsides
  • DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
  • Does not cause weight gain.
  • May be a good option for those with bad liver function.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
  • Humalog (insulin lispro) is the most effective medication for lowering your blood sugar.
  • Works quickly to control your sugar levels after meals.
  • Dose can be easily adjusted to create a regimen that's tailored to your body's needs.
  • Humalog (insulin lispro) can be used even if you have liver or kidney problems, unlike other anti-diabetic medications.
Downsides
  • Typically not first-choice treatment for diabetes.
  • Only lowers A1C (average blood sugar over time) by ~0.5%.
  • Risk for heart failure has not been seen in other medicines that work just like it.
  • May be more expensive than other anti-diabetic medicines.
  • You have to take Humalog (insulin lispro) by injection.
  • Humalog (insulin lispro) is likely to cause moderate weight gain (around 4 to 6 pounds).
  • There is a higher risk for episodes of low blood sugar compared to other anti-diabetic medications.
  • Effects do not last long enough to control your blood sugar for a whole day.
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Used for
Dosage forms
  • Pill
  • Injection
Price
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Reviews
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280 reviews so far
64%
saidit'sworth it
50%
saiditworked well
16%
saidit'sa big hassle

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Side effects
The Onglyza (saxagliptin) FDA package insert doesn’t have numbers about how common side effects are.
The Humalog (insulin lispro) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • inflammation of the pancreas
    • Alcoholism
    • Elevated triglycerides
    • History of pancreatitis
    • Gallstones
  • Heart failure
    • History of heart failure
    • Bad kidney function
  • Low blood sugar (hypoglycemia)
    • Alcohol
    • Unexpected changes in diet
    • Changes in amount of exercise
    • Taking other anti-diabetic medications
  • Severe allergic reactions
  • Severe joint pain
  • Fluid-filled blisters on the skin (bullous pemphigoid)
See more detailed risks and warnings
  • Life-threatening low blood sugar (hypoglycemia)
    • Insulin dose too high
    • Use of other blood sugar lowering medications
    • Poor injection techniques
  • Complications due to low potassium
    • Use of medications that lower potassium
    • Current electrolyte imbalance
  • Severe allergic reactions
    • Allergy to insulin
See more detailed risks and warnings