Compare Onglyza vs. Nesina

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Onglyza (saxagliptin)

Prescription only

Nesina (alogliptin)

Prescription only
Lowers blood sugar.

Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.

Lowers your blood sugar.

Nesina (alogliptin) is a good add-on treatment for diabetes if your blood sugars are still not controlled, but it doesn't work as well as insulin.

Upsides
  • DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
  • Does not cause weight gain.
  • May be a good option for those with bad liver function.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
  • Less likely to cause weight gain or low blood sugar compared to other anti-diabetic medicines.
  • Pill may be preferred by some patients over injection.
Downsides
  • Typically not first-choice treatment for diabetes.
  • Only lowers A1C (average blood sugar over time) by ~0.5%.
  • Risk for heart failure has not been seen in other medicines that work just like it.
  • May be more expensive than other anti-diabetic medicines.
  • Does not lower your A1c (average blood sugar over time) as much as insulin.
  • Available as an expensive, branded product only.
  • Has more troublesome side-effects than other anti-diabetic pills.
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Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
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Side effects
The Onglyza (saxagliptin) FDA package insert doesn’t have numbers about how common side effects are.
The Nesina (alogliptin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • inflammation of the pancreas
    • Alcoholism
    • Elevated triglycerides
    • History of pancreatitis
    • Gallstones
  • Heart failure
    • History of heart failure
    • Bad kidney function
  • Low blood sugar (hypoglycemia)
    • Alcohol
    • Unexpected changes in diet
    • Changes in amount of exercise
    • Taking other anti-diabetic medications
  • Severe allergic reactions
  • Severe joint pain
  • Fluid-filled blisters on the skin (bullous pemphigoid)
See more detailed risks and warnings
  • Pancreatitis (inflammation of the pancreas)
    • History of pancreatitis
    • High blood triglyceride levels
    • Gallstones (stones in gallbladder)
  • Liver damage
  • Serious allergic reactions
  • Low blood sugar (hypoglycemia)
    • Taking medicines for diabetes
  • Severe joint pain and swelling
See more detailed risks and warnings