Compare Onglyza vs. Prandin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Onglyza (saxagliptin)

Prescription only

Prandin (repaglinide)

Prescription only
Lowers blood sugar.

Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.

Lowers blood sugar.

Prandin (repaglinide) works quickly to lower blood sugar, especially during mealtimes. However, it can cause hypoglycemia (low blood sugar) if you are not consistent with your diet and exercise schedule.

Upsides
  • DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
  • Does not cause weight gain.
  • May be a good option for those with bad liver function.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
  • Quickly and effectively lowers blood sugar during meal times.
  • Less likely to cause hypoglycemia (low blood sugar) than Starlix (nateglinide).
  • Good first-choice if you cannot tolerate metformin or add-on therapy if your blood sugars are not controlled on metformin alone.
Downsides
  • Typically not first-choice treatment for diabetes.
  • Only lowers A1C (average blood sugar over time) by ~0.5%.
  • Risk for heart failure has not been seen in other medicines that work just like it.
  • May be more expensive than other anti-diabetic medicines.
  • May cause some weight gain.
  • May cause hypoglycemia (low blood sugar).
  • Can frequently interfere with how other medicines work.
  • Not a good choice if you have poor kidney function, liver problems, or younger than 18 years old.
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Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price
$432.40
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Lowest price
$20.30
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Side effects
The Onglyza (saxagliptin) FDA package insert doesn’t have numbers about how common side effects are.
20possible side effects
  • Low blood sugar
    31%
  • Headache
    11%
  • Sinusitis
    6%
  • Joint pain
    6%
  • Nausea
    5%
  • Diarrhea
    5%
  • Back pain
    5%
  • Swelling in arms and legs
    5%
  • Heart failure
    4%
  • Rhinitis
    3%
  • Constipation
    3%
  • Vomiting
    3%
  • Tingling, numbness, or burning sensation on the skin
    3%
  • Chest pain
    3%
  • Weight gain
    3%
  • Inflammation of the airways
    2%
  • Indigestion
    2%
  • Urinary tract infection
    2%
  • Tooth disorder
    2%
  • Allergy
    2%
See more detailed side effects
Risks and risk factors
  • inflammation of the pancreas
    • Alcoholism
    • Elevated triglycerides
    • History of pancreatitis
    • Gallstones
  • Heart failure
    • History of heart failure
    • Bad kidney function
  • Low blood sugar (hypoglycemia)
    • Alcohol
    • Unexpected changes in diet
    • Changes in amount of exercise
    • Taking other anti-diabetic medications
  • Severe allergic reactions
  • Severe joint pain
  • Fluid-filled blisters on the skin (bullous pemphigoid)
See more detailed risks and warnings
  • Low blood sugar (hypoglycemia)
    • Alcoholism
    • Changes in meal pattern
    • Changes in exercise
    • Insulin
    • Other antidiabetic medications
    • Elderly
    • Bad liver or kidney function
  • Heart damage
    • use with NPH-insulin
See more detailed risks and warnings
Learn more about Onglyza (saxagliptin)
Learn more about Prandin (repaglinide)