Compare Onzetra vs. Relpax

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Onzetra (sumatriptan)

Prescription only

Relpax (eletriptan)

Prescription only
Treats migraine headaches.

Onzetra (sumatriptan) is the only medicine that's available in a breath-powered nose powder to treat migraines. However, it can be expensive compared to other medicines.

Treats migraine headaches.

Relpax (eletriptan) is a first choice medicine to treat migraines, but it can be expensive.

Upsides
  • Compared to pills, Onzetra (sumatriptan) is better absorbed in the body and good if it's hard to take pills.
  • Onzetra (sumatriptan) is a first choice medicine to treat migraines.
  • There is a copay program available that can make Onzetra (sumatriptan) cheaper.
  • Relpax (eletriptan) works as well as other first choice medicines for migraines.
  • Relpax (eletriptan) comes in 2 different strengths.
Downsides
  • It can be very expensive. There are other forms of this same medicine that are much cheaper, including a nose spray.
  • You have to use two nosepieces to get the full dose of Onzetra (sumatriptan), which can be hard to remember.
  • Onzetra (sumatriptan) is only available in one strength.
  • Relpax (eletriptan) is only available as a brand name.
  • Relpax (eletriptan) can cause dizziness and might make you more likely to fall.
  • If you have more than 3 migraines a month, Relpax (eletriptan) isn't a good choice because of its side effects.
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Used for
Dosage forms
  • Nasal powder
  • Pill
Price
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Reviews
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Side effects
4possible side effects
  • Changes in taste
    20%
  • Discomfort in the nose
    11%
  • Runny nose
    5%
  • Stuffy nose
    2%
See more detailed side effects
8possible side effects
  • Nausea
    4%
  • Headache
    4%
  • Weakness
    4%
  • Tingling or prickling sensation
    3%
  • Dizziness
    3%
  • Sleepiness
    3%
  • Flushing
    2%
  • Dry mouth
    2%
See more detailed side effects
Risks and risk factors
  • Heart attack
    • Heart disease
    • History of chest pain
    • Uncontrolled high blood pressure
  • Stroke
    • History of a stroke
  • Medication overuse headache
    • Using Onzetra (sumatriptan) for more than 10 days a month
  • Serotonin syndrome
    • Tricyclic antidepressants
    • Fentanyl
    • Tramadol
    • Buspirone
    • ADHD medicines
    • Triptans
  • Higher blood pressure
    • Uncontrolled high blood pressure
  • Suicidal behavior
    • Taking medicines for seizures
  • Blood vessel issues
    • High blood pressure
    • History of stroke
See more detailed risks and warnings
  • Heart attack and rhythm problems
    • Heart rhythm problems
    • History of chest pain
    • Uncontrolled high blood pressure
  • Stroke
    • History of a stroke
  • Medication overuse headache
    • Using Relpax (eletriptan) for more than 10 days a month
  • Serotonin syndrome
    • Tricyclic antidepressants
    • Fentanyl
    • Tramadol
    • Buspirone
    • ADHD medicines
    • Triptans
  • Higher blood pressure
    • Uncontrolled high blood pressure
  • Blood vessel issues
    • High blood pressure
    • History of stroke
    • History of heart attack
See more detailed risks and warnings