Compare Onzetra vs. Zomig

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Onzetra (sumatriptan)

Prescription only

Zomig (zolmitriptan)

Prescription only
Treats migraine headaches.

Onzetra (sumatriptan) is the only medicine that's available in a breath-powered nose powder to treat migraines. However, it can be expensive compared to other medicines.

Treats migraines.

Triptans are the first-choice to treat migraines. Zomig (zolmitriptan) works just as well as other triptans for migraines.

Upsides
  • Compared to pills, Onzetra (sumatriptan) is better absorbed in the body and good if it's hard to take pills.
  • Onzetra (sumatriptan) is a first choice medicine to treat migraines.
  • There is a copay program available that can make Onzetra (sumatriptan) cheaper.
  • Zomig (zolmitriptan) is is a first choice treatment to treat severe migraines.
  • There are different forms of Zomig (zolmitriptan) available, including a dissolving pill and a nasal spray if you have trouble swallowing during a migraine attack.
  • The regular and dissolving pill forms of Zomig (zolmitriptan) are available as generics.
Downsides
  • It can be very expensive. There are other forms of this same medicine that are much cheaper, including a nose spray.
  • You have to use two nosepieces to get the full dose of Onzetra (sumatriptan), which can be hard to remember.
  • Onzetra (sumatriptan) is only available in one strength.
  • If you're taking the nasal spray form of Zomig (zolmitriptan), you have to follow the instructions exactly or you won't get the full dose of medicine.
  • The nasal spray form of Zomig (zolmitriptan) is only available as brand name, so it can be expensive.
  • If you have heart disease or history of stroke, Zomig (zolmitriptan) may not be the best choice for you. Talk to your doctor about your medical history.
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Used for
Dosage forms
  • Nasal powder
  • Pill
  • Dissolving tablet
  • Nasal spray
Price
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Reviews
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Side effects
4possible side effects
  • Changes in taste
    20%
  • Discomfort in the nose
    11%
  • Runny nose
    5%
  • Stuffy nose
    2%
See more detailed side effects
12possible side effects
  • Changes in taste
    21%
  • Tingling or prickling sensation
    10%
  • Oversensitivity of the skin
    5%
  • Pain
    4%
  • Pain in the throat
    4%
  • Nausea
    4%
  • Sleepiness
    4%
  • Discomfort in the nose
    3%
  • Dizziness
    3%
  • Weakness
    3%
  • Tightness in the throat
    2%
  • Dry mouth
    2%
See more detailed side effects
Risks and risk factors
  • Heart attack
    • Heart disease
    • History of chest pain
    • Uncontrolled high blood pressure
  • Stroke
    • History of a stroke
  • Medication overuse headache
    • Using Onzetra (sumatriptan) for more than 10 days a month
  • Serotonin syndrome
    • Tricyclic antidepressants
    • Fentanyl
    • Tramadol
    • Buspirone
    • ADHD medicines
    • Triptans
  • Higher blood pressure
    • Uncontrolled high blood pressure
  • Suicidal behavior
    • Taking medicines for seizures
  • Blood vessel issues
    • High blood pressure
    • History of stroke
See more detailed risks and warnings
  • Heart attack
    • Heart disease
    • history of chest pain/angina
    • uncontrolled high blood pressure
  • Stroke
    • History of a stroke
  • Medication overuse headache
    • Using Zomig (zolmitriptan) or other migraine treatment medications for 10 or more days a month
  • Changes in heartbeat
    • History of arrhythmia
  • Serotonin syndrome
    • Taking tricyclic antidepressants, fentanyl, tramadol, buspirone, or ADHD medicines
  • Blood vessel issues
    • High blood pressure
    • history of stroke
See more detailed risks and warnings