Compare oxycodone vs. Dilaudid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

ADVERTISEMENT

Oxycontin (oxycodone)

Prescription only

Dilaudid (hydromorphone)

Prescription only
Treats moderate to severe pain.

Oxycontin (oxycodone) treats moderate to severe pain, but can be habit-forming, especially if used long-term.

3.8/ 5 average rating with 1241 reviewsforoxycodone
Treats moderate to severe pain.

Dilaudid (hydromorphone) is a powerful pain reliever that has significant risks for abuse and overdose.

4.1/ 5 average rating with 51 reviewsforDilaudid
Upsides
  • Oxycontin (oxycodone) is available in a tamper-resistant form to lessen the risk of abuse.
  • Liquid form is available if you have trouble swallowing.
  • Available in a generic version.
  • The extended-release pill provides around-the-clock pain relief with convenient once or twice daily dosing.
  • Dilaudid (hydromorphone) works better and faster at relieving pain than morphine.
  • Available in a cheap generic version.
Downsides
  • Constipation, dizziness, drowsiness, and nausea commonly occur.
  • Long-term use can cause dependence and tolerance.
  • Not effective in treating all kinds of pain.
  • It’s not safe to start taking extended-release pills if you've never taken an opioid medicine before.
  • Constipation is a common side effect of Dilaudid (hydromorphone) and may require the use of laxatives or stool softeners.
  • Dilaudid (hydromorphone) is fatal when combined with alcohol, muscle relaxants, and other medications that slow breathing.
  • Long-term use of opioids will cause physical dependence.
ADVERTISEMENT
Used for
  • Pain management
Dosage forms
  • Pill
  • Extended-release pill
  • Liquid
  • Pill
  • Extended release pill
  • Liquid
  • Suppository
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
1241 reviews so far
66%
saidit'sworth it
50%
saiditworked well
19%
saidit'sa big hassle

Have you used Oxycontin (oxycodone)?

Leave a review
51 reviews so far
78%
saidit'sworth it
65%
saiditworked well
10%
saidit'sa big hassle

Have you used Dilaudid (hydromorphone)?

Leave a review
Side effects
10possible side effects
  • Constipation
    23%
  • Nausea
    23%
  • Sleepiness
    23%
  • Dizziness
    13%
  • Itchiness
    13%
  • Vomiting
    12%
  • Headache
    7%
  • Dry mouth
    6%
  • Weakness
    6%
  • Sweating
    5%
See more detailed side effects
The Dilaudid (hydromorphone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Slowed breathing
    • Age 65 or greater
    • High dosages
    • After dose change
    • History of lung problems
    • Taking other painkillers or sedatives
  • Harm to newborn babies
    • Long-term use during pregnancy
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
    • Younger age
  • Interactions with other medicines
    • Taking medicines that also cause sleepiness or slowed breathing
  • Confusion and drowsiness
    • Age 65 or greater
    • High dosages
    • Taking other painkillers or sedatives
  • Death from overdose
    • Taking alcohol, other opioids, or benzodiazepines
    • Children age 18 and younger
See more detailed risks and warnings
  • Slowed breathing
    • Current use of medicine that affects liver enzyme CYP 3A4
    • Age 65 or greater
    • Higher doses
    • Drinking alcohol
    • Use with benzodiazepines
  • Death from overdose
    • Children age 18 and younger
  • Death of newborn babies from opioid withdrawal
    • Long-term use during pregnancy
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
  • Driving impairment
    • Taking Dilaudid (hydromorphone) with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
See more detailed risks and warnings