Compare oxycodone vs. methadone

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Oxycontin (oxycodone)

Prescription only

Methadose (methadone)

Prescription only
Treats moderate to severe pain.

Oxycontin (oxycodone) treats moderate to severe pain, but can be habit-forming, especially if used long-term.

3.8/ 5 average rating with 1241 reviewsforoxycodone
Treats severe pain or drug dependence.

Methadose (methadone) is a cheap and effective treatment for severe chronic pain, but has serious risks for fatal overdose and drug dependence.

  • Oxycontin (oxycodone) is available in a tamper-resistant form to lessen the risk of abuse.
  • Liquid form is available if you have trouble swallowing.
  • Available in a generic version.
  • The extended-release pill provides around-the-clock pain relief with convenient once or twice daily dosing.
  • Available as a cheap, generic version.
  • One of the stronger opioid medicines for treatment of severe pain.
  • Can also be used to treat opioid dependence as part of a complete recovery program.
  • Constipation, dizziness, drowsiness, and nausea commonly occur.
  • Long-term use can cause dependence and tolerance.
  • Not effective in treating all kinds of pain.
  • It’s not safe to start taking extended-release pills if you've never taken an opioid medicine before.
  • Methadose (methadone) can cause slowed breathing, coma, and death from overdose, especially if mixed with alcohol, sleeping pills, or muscle relaxants.
  • Constipation is a common side effect of Methadose (methadone) and you might need laxatives or stool softeners.
  • Not a good option for short-term pain relief.
Used for
Dosage forms
  • Pill
  • Extended-release pill
  • Liquid
  • Pill
  • Dissolving tablet
  • Liquid
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
1241 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Oxycontin (oxycodone)?

Leave a review
Not enough review data.Leave a review
Side effects
10possible side effects
  • Constipation
  • Nausea
  • Sleepiness
  • Dizziness
  • Itchiness
  • Vomiting
  • Headache
  • Dry mouth
  • Weakness
  • Sweating
See more detailed side effects
The Methadose (methadone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Slowed breathing
    • Age 65 or greater
    • High dosages
    • After dose change
    • History of lung problems
    • Taking other painkillers or sedatives
  • Harm to newborn babies
    • Long-term use during pregnancy
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
    • Younger age
  • Interactions with other medicines
    • Taking medicines that also cause sleepiness or slowed breathing
  • Confusion and drowsiness
    • Age 65 or greater
    • High dosages
    • Taking other painkillers or sedatives
  • Death from overdose
    • Taking alcohol, other opioids, or benzodiazepines
    • Children age 18 and younger
See more detailed risks and warnings
  • Death from lack of oxygen to the body (respiratory depression)
    • Start of treatment
    • Age 65 or greater
    • Dose changes and higher doses
  • Heart problems (arrhythmia)
    • History of cardiovascular disease
  • Driving impairment
    • Taking Methadose (methadone) with alcohol
    • Taking other medicines that make you less alert
  • Death from overdose
    • Children age 18 and younger
    • Taking more than prescribed dose
    • Mixing with alcohol or drugs that interact with Methadose (methadone)
  • Abuse, tolerance, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse or mental illness
See more detailed risks and warnings