Compare Pamelor vs. lidocaine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Improves mood.

Pamelor (nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain, but may take 6 to 8 weeks to feel the full effects on your mood.

4.0/ 5 average rating with 19 reviewsforPamelor
Treats nerve pain.

Lidoderm (lidocaine) works well to treat nerve pain that is localized to a small area, but its topical application may cause minor skin irritation.

4.2/ 5 average rating with 18 reviewsforlidocaine
Upsides
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
  • Available as a generic in 2 different forms: capsule and liquid.
  • Minimal side-effects compared to other pain relievers since it works locally at the site of application.
  • Won't hurt your kidneys or liver unlike other pain relievers.
  • Available in many different topical formulations to fit your needs.
Downsides
  • Side effects are usually manageable, but can be annoying.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
  • Application may cause minor stinging or burning skin irritation.
  • Used patches requires proper medication disposal since it still contain enough medicine to be dangerous to children and pets.
  • Not a good choice if you've had allergic reactions to numbing medications (local anesthetics) or have a history of irregular heartbeats.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Cream
  • Gel
  • Ointment
  • Jelly
  • Spray
  • Patch
  • Lotion
  • Topical solution
Price
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Reviews
19 reviews so far
79%
saidit'sworth it
79%
saiditworked well
21%
saidit'sa big hassle

Have you used Pamelor (nortriptyline)?

Leave a review
18 reviews so far
67%
saidit'sworth it
72%
saiditworked well
22%
saidit'sa big hassle

Have you used Lidoderm (lidocaine)?

Leave a review
Side effects
The Pamelor (nortriptyline) FDA package insert doesn’t have numbers about how common side effects are.
The Lidoderm (lidocaine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
    • Changing the dose
  • Dizziness and falls
    • Age 65 years or older
    • Other blood pressure lowering medications
  • Eye problems
    • Glaucoma
  • Rare, life-threatening
    • Antidepressants
    • Lithium
    • Triptans
    • St. John's wort
    • Fentanyl
    • Tramadol
    • MAO inhibitors
  • Heart problems
    • History of heart disease
    • Older age
    • Electrolyte imbalance
See more detailed risks and warnings
  • Overdose
    • Use of heating pad on skin
    • Applying patch to red, irritated or broken skin
    • Leaving patch on for more than 12 hours
    • Using patch on a very large area
    • Older age
    • Smaller patients
    • Liver disease
  • Accidental poisoning
    • Not disposing of Lidoderm (lidocaine) correctly
  • Eye irritation
    • Not washing hands after touching or applying Lidoderm (lidocaine)
  • Skin reactions
    • Applying Lidoderm (lidocaine) to warm skin
    • Covering patch with wrap or heating pad
  • Heart problems
    • History of heart problems
    • Using Lidoderm (lidocaine) with medications to treat irregular heartbeat
See more detailed risks and warnings