Compare Pamelor vs. Zoloft

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Pamelor (nortriptyline)

Prescription only

Zoloft (sertraline)

Prescription only
Improves mood.

Pamelor (nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain, but may take 6 to 8 weeks to feel the full effects on your mood.

4.0/ 5 average rating with 19 reviewsforPamelor
Improves mood and helps you relax.

Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines.

3.5/ 5 average rating with 1472 reviewsforZoloft
Upsides
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
  • Available as a generic in 2 different forms: capsule and liquid.
  • One of the more effective and better tolerated antidepressants in its class.
  • Causes less sleepiness than other antidepressants.
  • Available as a generic, which is cheaper.
  • Best choice among antidepressants if you are pregnant.
Downsides
  • Side effects are usually manageable, but can be annoying.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect.
  • Can cause low sex drive, an inability to orgasm or ejaculate, and minor weight gain (1 to 5 pounds).
  • Is more likely to cause diarrhea compared to other antidepressants.
  • Interacts with lots of other medicines.
  • You may need to try out several different antidepressants before you find the one that works for you.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Liquid
Price
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Reviews
19 reviews so far
79%
saidit'sworth it
79%
saiditworked well
21%
saidit'sa big hassle

Have you used Pamelor (nortriptyline)?

Leave a review
1472 reviews so far
59%
saidit'sworth it
41%
saiditworked well
15%
saidit'sa big hassle

Have you used Zoloft (sertraline)?

Leave a review
Side effects
The Pamelor (nortriptyline) FDA package insert doesn’t have numbers about how common side effects are.
15possible side effects
  • Nausea
    26%
  • Diarrhea
    18%
  • Dry mouth
    16%
  • Difficulty sleeping
    16%
  • Drowsiness
    13%
  • Dizziness
    12%
  • Tremor
    11%
  • Fatigue
    11%
  • More sweating
    8%
  • Constipation
    8%
  • Ejaculation failure
    7%
  • Upset stomach
    6%
  • Agitation
    6%
  • Loss of appetite
    3%
  • Stomach pain
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
    • Changing the dose
  • Dizziness and falls
    • Age 65 years or older
    • Other blood pressure lowering medications
  • Eye problems
    • Glaucoma
  • Rare, life-threatening
    • Antidepressants
    • Lithium
    • Triptans
    • St. John's wort
    • Fentanyl
    • Tramadol
    • MAO inhibitors
  • Heart problems
    • History of heart disease
    • Older age
    • Electrolyte imbalance
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Taking other medicines that affect serotonin levels
  • Mania
    • Personal history of bipolar disorder
    • Family history for bipolar disorder
  • Withdrawal
    • Stopping Zoloft (sertraline) suddenly
  • Increased bleeding
    • Taking blood thinners
  • Low sodium levels in the blood
    • Older people
    • Taking diuretic medicines
See more detailed risks and warnings