Compare pantoprazole vs. Pepto-Bismol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats heartburn and excess release of stomach acid.

Protonix (pantoprazole) is usually only taken once a day for long-lasting heartburn relief, but it can increase your risk of bone fractures if you've used it for a long time.

3.8/ 5 average rating with 584 reviewsforpantoprazole
Relieves heartburn, upset stomach, and diarrhea.

Pepto-Bismol (bismuth subsalicylate) can help for many stomach and intestinal problems, but may take longer to work compared to some other anti-diarrheal medicines.

3.9/ 5 average rating with 1376 reviewsforPepto-Bismol
Upsides
  • Most people can take Protonix (pantoprazole) without any noticeable day-to-day side effects.
  • Protonix (pantoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
  • Can be used in children age 5 or older.
  • Pepto-Bismol (bismuth subsalicylate) works well to alleviate stomach and intestinal problems and doesn't have many side effects.
  • Comes in easy to take chewable pills or liquid, if you do not like swallowing pills.
  • Is inexpensive and available over the counter.
  • Coupons are available. Speak to your doctor or pharmacist.
Downsides
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Needs to be taken every single day for a certain period of time to be effective.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Only available as a prescription medicine, not over the counter.
  • Can lower the magnesium level in your body so you may need to take a supplement for it.
  • May not be as strong as other anti-diarrheal or antacid medications.
  • Should not be used for more than 2 days if your diarrhea does not go away or if you have a fever.
  • For symptoms other than diarrhea, should not be used for more than 7 days without your doctor's approval. Speak to your doctor if symptoms persist.
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Used for
Dosage forms
  • Pill
  • Packet
  • Chewable tablet
  • Liquid
  • Pill
Price
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Reviews
584 reviews so far
68%
saidit'sworth it
51%
saiditworked well
13%
saidit'sa big hassle

Have you used Protonix (pantoprazole)?

Leave a review
1376 reviews so far
84%
saidit'sworth it
48%
saiditworked well
6%
saidit'sa big hassle

Have you used Pepto-Bismol (bismuth subsalicylate)?

Leave a review
Side effects
8possible side effects
  • Headache
    12%
  • Diarrhea
    9%
  • Nausea
    7%
  • Stomach pain
    6%
  • Vomiting
    4%
  • Gas
    4%
  • Dizziness
    3%
  • Joint pain
    3%
See more detailed side effects
The Pepto-Bismol (bismuth subsalicylate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Weakened bones
    • Using multiple daily doses and/or for 1 year or longer
    • People age 65 or older
    • High risk of bone fractures
  • Severe diarrhea
    • People who are being treated in the hospital
  • Kidney problem
  • Lupus
    • People with lupus
  • Low Vitamin B-12 level
    • Taking Protonix (pantoprazole) for more than 3 years
  • Low magnesium level
    • Diuretics (water pills)
    • Digoxin
See more detailed risks and warnings
  • Reye's syndrome
    • Children or teenagers that have or are recovering from flu/flu-like symptoms or chickenpox
  • Allergy to salicylates
    • Aspirin allergy
    • NSAID allergy
  • Hearing problems
    • Age 60 or older
  • Drug Interactions
    • Anticoagulants
    • Aspirin-containing medications
See more detailed risks and warnings