Compare pantoprazole vs. Rolaids

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats heartburn and excess release of stomach acid.

Protonix (pantoprazole) is usually only taken once a day for long-lasting heartburn relief, but it can increase your risk of bone fractures if you've used it for a long time.

3.8/ 5 average rating with 584 reviewsforpantoprazole
Relieves heartburn and acid tummy.

Rolaids (Calcium Carbonate / Magnesium Hydroxide) gives quick relief for heartburn, but don't expect it to last all day.

3.7/ 5 average rating with 1089 reviewsforRolaids
Upsides
  • Most people can take Protonix (pantoprazole) without any noticeable day-to-day side effects.
  • Protonix (pantoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
  • Can be used in children age 5 or older.
  • Works really fast.
  • Available over the counter without a prescription.
  • Cheap.
Downsides
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Needs to be taken every single day for a certain period of time to be effective.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Only available as a prescription medicine, not over the counter.
  • Can lower the magnesium level in your body so you may need to take a supplement for it.
  • Doesn't last very long.
  • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
  • Some chalky aftertaste.
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Used for
Dosage forms
  • Pill
  • Packet
  • Chewable tablet
  • Liquid
Price
No pricing information available
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Reviews
584 reviews so far
68%
saidit'sworth it
51%
saiditworked well
13%
saidit'sa big hassle

Have you used Protonix (pantoprazole)?

Leave a review
1089 reviews so far
75%
saidit'sworth it
37%
saiditworked well
7%
saidit'sa big hassle

Have you used Rolaids (Calcium Carbonate / Magnesium Hydroxide)?

Leave a review
Side effects
8possible side effects
  • Headache
    12%
  • Diarrhea
    9%
  • Nausea
    7%
  • Stomach pain
    6%
  • Vomiting
    4%
  • Gas
    4%
  • Dizziness
    3%
  • Joint pain
    3%
See more detailed side effects
The Rolaids (Calcium Carbonate / Magnesium Hydroxide) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Weakened bones
    • Using multiple daily doses and/or for 1 year or longer
    • People age 65 or older
    • High risk of bone fractures
  • Severe diarrhea
    • People who are being treated in the hospital
  • Kidney problem
  • Lupus
    • People with lupus
  • Low Vitamin B-12 level
    • Taking Protonix (pantoprazole) for more than 3 years
  • Low magnesium level
    • Diuretics (water pills)
    • Digoxin
See more detailed risks and warnings
  • Taking the wrong medication
  • High blood calcium
    • Current kidney disease
    • Kidney dialysis
    • Hyperparathyroid disease
    • Taking high doses of Vitamin D
  • Kidney stones
    • Previous kidney stones
See more detailed risks and warnings