Compare pantoprazole vs. Tagamet

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Protonix (pantoprazole)

Prescription only

Tagamet (cimetidine)

Prescription or OTC
Treats heartburn and excess release of stomach acid.

Protonix (pantoprazole) is usually only taken once a day for long-lasting heartburn relief, but it can increase your risk of bone fractures if you've used it for a long time.

3.8/ 5 average rating with 584 reviewsforpantoprazole
Treats heartburn.

Tagamet (cimetidine) works well for heartburn, but may have more side effects than other medicines like it.

3.4/ 5 average rating with 632 reviewsforTagamet
  • Most people can take Protonix (pantoprazole) without any noticeable day-to-day side effects.
  • Protonix (pantoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
  • Can be used in children age 5 or older.
  • Lasts longer than other medicines like it so you may not need to take it as frequently.
  • Affordable as an over-the-counter or generic medicine.
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Needs to be taken every single day for a certain period of time to be effective.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Only available as a prescription medicine, not over the counter.
  • Can lower the magnesium level in your body so you may need to take a supplement for it.
  • Does not work as fast as antacids like Maalox, Tums, or Rolaids.
  • May not work as well if you have an inflammed esophagus. Your doctor will assess which medicine is best for you.
  • May not be the best option if you are elderly or have kidney or liver problems.
  • Can interfere with how other medicines work.
Used for
Dosage forms
  • Pill
  • Packet
  • Pill
  • Liquid
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584 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Protonix (pantoprazole)?

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632 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Tagamet (cimetidine)?

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Side effects
8possible side effects
  • Headache
  • Diarrhea
  • Nausea
  • Stomach pain
  • Vomiting
  • Gas
  • Dizziness
  • Joint pain
See more detailed side effects
The Tagamet (cimetidine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Weakened bones
    • Using multiple daily doses and/or for 1 year or longer
    • People age 65 or older
    • High risk of bone fractures
  • Severe diarrhea
    • People who are being treated in the hospital
  • Kidney problem
  • Lupus
    • People with lupus
  • Low Vitamin B-12 level
    • Taking Protonix (pantoprazole) for more than 3 years
  • Low magnesium level
    • Diuretics (water pills)
    • Digoxin
See more detailed risks and warnings
  • Confusion
    • Elderly
    • Kidney problems
    • Liver problems
    • Dementia
  • Drug interactions
  • Chronic lung problems
    • Asthma
    • COPD
    • Lung problems
  • Clostridium difficile associated diarrhea
    • Taking antibiotics
  • Englarged breasts in men (gynecomastia)
See more detailed risks and warnings