Compare Pepcid vs. omeprazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Pepcid (Famotidine)

Prescription or OTC

Prilosec (omeprazole)

Prescription or OTC
Relieves heartburn.

Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.

3.7/ 5 average rating with 853 reviewsforPepcid
Treats heartburn and excess release of stomach acid.

Prilosec (omeprazole) gives you long-lasting heartburn relief but has some risks if used long term.

4.0/ 5 average rating with 1167 reviewsforomeprazole
Upsides
  • Most people can take Famotidine without any noticeable day-to-day side effects.
  • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Few drug interactions.
  • Prilosec (omeprazole) lasts longer (up to 72 hours) than other classes of acid reducers (like Zantac, Pepcid, or Tums).
  • Only take once or twice daily.
  • Can take together with a quick-acting antacid (like Maalox or Tums) for quick relief.
  • Generic and over-the-counter options available.
  • Safe to use in children ages 1 or older.
Downsides
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
  • Takes up to an hour to start noticing the effects of Prilosec (omeprazole).
  • Prilosec (omeprazole) can interact with other drugs. Let your doctor and pharmacist know what medications you're taking before starting Prilosec (omeprazole).
  • Long-term use of Prilosec (omeprazole) can put you at risk for many health issues such as osteoporosis, low magnesium or vitamin B12 levels, and rebound acid secretion (where your body starts to create more acid than before after stoping Prilosec (omeprazole)).
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Used for
Dosage forms
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
  • Powder
Price
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Reviews
853 reviews so far
75%
saidit'sworth it
41%
saiditworked well
8%
saidit'sa big hassle

Have you used Pepcid (Famotidine)?

Leave a review
1167 reviews so far
80%
saidit'sworth it
59%
saiditworked well
8%
saidit'sa big hassle

Have you used Prilosec (omeprazole)?

Leave a review
Side effects
2possible side effects
  • Headache
    5%
  • Diarrhea
    2%
See more detailed side effects
11possible side effects
  • Headache
    7%
  • Abdominal pain
    5%
  • Nausea
    4%
  • Diarrhea
    4%
  • Vomiting
    3%
  • Flatulence
    3%
  • Acid regurgitation
    2%
  • Upper respiratory infection
    2%
  • Constipation
    2%
  • Dizziness
    2%
  • Rash
    2%
See more detailed side effects
Risks and risk factors
  • Hiding possible cancer
  • Increased side effects
    • Current kidney disease
  • Allergic reaction
See more detailed risks and warnings
  • Risk of cancer
  • Lupus
    • History of cutaneous or systemic lupus erythematosus
  • Severe diarrhea associated with C.difficile infection
    • Being hospitalized
    • Antibiotic use
  • Bone fractures
    • Osteoporosis
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Use of other medications that weaken bones
  • Low Vitamin B12 and Magnesium
    • Taking water pills (Magnesium)
    • Women (Vitamin B12)
    • Over the age of 30 (Vitamin B12)
  • Kidney damage
See more detailed risks and warnings