Compare Percocet vs. methadone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats moderate to severe pain.

Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

3.8/ 5 average rating with 1399 reviewsforPercocet
Treats severe pain or drug dependence.

Methadose (methadone) is a cheap and effective treatment for severe chronic pain, but has serious risks for fatal overdose and drug dependence.

Upsides
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
  • Available as a cheap, generic version.
  • One of the stronger opioid medicines for treatment of severe pain.
  • Can also be used to treat opioid dependence as part of a complete recovery program.
Downsides
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
  • Methadose (methadone) can cause slowed breathing, coma, and death from overdose, especially if mixed with alcohol, sleeping pills, or muscle relaxants.
  • Constipation is a common side effect of Methadose (methadone) and you might need laxatives or stool softeners.
  • Not a good option for short-term pain relief.
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Used for
Dosage forms
  • Pill
  • Oral solution
  • Pill
  • Dissolving tablet
  • Liquid
Price
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Reviews
1399 reviews so far
70%
saidit'sworth it
49%
saiditworked well
15%
saidit'sa big hassle

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Side effects
The Percocet (Oxycodone / Acetaminophen) FDA package insert doesn’t have numbers about how common side effects are.
The Methadose (methadone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Death from liver failure
    • Current liver disease
    • Taking with alcohol
    • Taking other medicines with acetaminophen
  • Death from lack of oxygen to the body (respiratory depression)
    • Age 65 or greater
    • Higher dose
    • People with not enough thyroid hormones
    • History of lung problems
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Tolerance and dependence
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
  • Neonatal withdrawal syndrome
    • Long-term use of opioids in mother
    • Breastfeeding while taking Percocet (Oxycodone / Acetaminophen)
  • Death from overdose (extended-release tablet)
    • Children age 18 and younger
    • Taking more than prescribed dose
    • Mixing with alcohol or drugs that interact with Percocet (Oxycodone / Acetaminophen)
  • Severe allergic reactions
  • Low blood pressure
    • Age 65 years or older
    • Circulation problems
See more detailed risks and warnings
  • Death from lack of oxygen to the body (respiratory depression)
    • Start of treatment
    • Age 65 or greater
    • Dose changes and higher doses
  • Heart problems (arrhythmia)
    • History of cardiovascular disease
  • Driving impairment
    • Taking Methadose (methadone) with alcohol
    • Taking other medicines that make you less alert
  • Death from overdose
    • Children age 18 and younger
    • Taking more than prescribed dose
    • Mixing with alcohol or drugs that interact with Methadose (methadone)
  • Abuse, tolerance, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse or mental illness
See more detailed risks and warnings