Compare perphenazine vs. Clozaril
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Treats schizophrenia.
Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.
Helps control your thoughts and actions.
Clozaril (clozapine) treats schizophrenia when other drugs haven't worked, but you'll have to get regular blood work done because it can have very serious side effects.
Upsides
- Trilafon (perphenazine) can be much cheaper than other medicines.
- Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
- Studies show that Clozaril (clozapine) effectively treats schizophrenia when other medications have failed. Clozaril (clozapine) also reduces risk of suicidal behavior.
- Has the lowest risk of causing movement problems when compared to other antipsychotic medicines.
- Clozaril (clozapine) is available as a normal tablet and as a mint-flavored tablet that dissolves on the tongue without water.
- Safer than other similar medicines during pregnancy.
- Available as a generic, which is cheaper.
Downsides
- You're more likely to gain weight.
- You can be more sensitive to temperature changes.
- You're more likely to catch colds and flu.
- You need to get blood work done every time you get a prescription filled for Clozaril (clozapine). Once it is ready at the pharmacy, you need to pick it up within 7 days.
- You can only get Clozaril (clozapine) at certain pharmacies that are registered to provide it.
- You need to limit the amount of alcohol you drink while taking Clozaril (clozapine).
- Clozaril (clozapine) can cause high blood sugar, high cholesterol, and weight gain.
- May not be optimal for someone with a history of seizures.
Used for
- Schizophrenia
- Suicidal behavior in schizophrenia
- Psychosis in Parkinson's disease
Dosage forms
- Pill
- Pill
- Dissolving tablet
- Liquid
Price
Lowest price
$38.60
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$807.38
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Side effects
The Trilafon (perphenazine) FDA package insert doesn’t have numbers about how common side effects are.
31possible side effects
- Drowsiness/sedation39%
- Salivation31%
- Fast heartbeat25%
- Dizziness/vertigo19%
- Constipation14%
- Low blood pressure9%
- Headache7%
- Tremor6%
- Fainting6%
- Sweating6%
- Dry mouth6%
- Nausea5%
- Vision problems5%
- Fever5%
- Disturbed sleep/nightmares4%
- Restlessness4%
- Loss of muscle movement4%
- Agitation4%
- High blood pressure4%
- Stomach discomfort/heartburn4%
- Weight gain4%
- Seizures (convulsions)3%
- Rigidity3%
- Confusion3%
- Nausea/vomiting3%
- Low white blood cells3%
- Fatigue2%
- Trouble sleeping2%
- Diarrhea2%
- Problems urinating2%
- Rash2%
Risks and risk factors
- Higher risk of death
- People age 65 or older with dementia and psychosis
- Difficulty controlling movements
- Higher risk for falls
- Sleepiness
- Drinking alcohol or taking narcotics
- Higher risk of infection
- Low white blood cells
- Low blood pressure, slow heartbeat, and fainting
- Dehydration
- Taking blood pressure medications
- Heart failure
- Seizures
- Seizure disorder
- Alcohol abuse
- Heart problems
- History of heart problems
- Increased risk of death in elderly with dementia
- Over 65 with dementia
- High blood sugar, high cholesterol, and weight gain