Compare perphenazine vs. fluphenazine decanoate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats schizophrenia.

Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.

Treats schizophrenia or psychosis.

Prolixin Decanoate (fluphenazine decanoate) is long-acting medicine for stabilizing your mood that must be given by a trained healthcare professional.

Upsides
  • Trilafon (perphenazine) can be much cheaper than other medicines.
  • Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
  • Can be given less frequently than the oral, short-acting version.
  • Available in generic.
Downsides
  • You're more likely to gain weight.
  • You can be more sensitive to temperature changes.
  • You're more likely to catch colds and flu.
  • Can make you sensitive to the sun.
  • Can affect how your body regulates your temperature.
  • Can only be used if you're already stable on the short-acting version of this medicine.
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Used for
Dosage forms
  • Pill
  • Injection
Price
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Reviews
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Side effects
The Trilafon (perphenazine) FDA package insert doesn’t have numbers about how common side effects are.
The Prolixin Decanoate (fluphenazine decanoate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Higher risk of death
    • People age 65 or older with dementia and psychosis
  • Difficulty controlling movements
  • Higher risk for falls
  • Sleepiness
    • Drinking alcohol or taking narcotics
  • Higher risk of infection
See more detailed risks and warnings
  • Increased risk of death
    • People over 65 with dementia and psychosis
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Low white blood cell count
See more detailed risks and warnings