Compare perphenazine vs. Geodon

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Trilafon (perphenazine)

Prescription only

Geodon (ziprasidone)

Prescription only
Treats schizophrenia.

Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.

Helps control your thoughts and mood.

Geodon (ziprasidone) treats bipolar disorder and schizophrenia with fewer side effects than similar medications, but has a risk of abnormal heart rhythm.

3.4/ 5 average rating with 23 reviewsforGeodon
Upsides
  • Trilafon (perphenazine) can be much cheaper than other medicines.
  • Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
  • Geodon (ziprasidone) effectively stabilizes mood in schizophrenia and bipolar disorder.
  • Compared to other antipsychotics, this drug has a lower risk of weight gain, high blood sugars, and high cholesterol.
  • Geodon (ziprasidone) capsule is available as a generic.
  • Available as a daily pill for long-term treatment.
Downsides
  • You're more likely to gain weight.
  • You can be more sensitive to temperature changes.
  • You're more likely to catch colds and flu.
  • It may take several weeks before you feel the full effects of Geodon (ziprasidone).
  • Might not be a good option if you have a history of heart problems.
  • You will need to get blood tests before you start taking Geodon (ziprasidone) to make sure you're healthy enough to take it.
  • People who are also taking diuretics will need regular blood tests while on Geodon (ziprasidone).
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Used for
Dosage forms
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  • Pill
Price
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Reviews
Not enough review data.Leave a review
23 reviews so far
43%
saidit'sworth it
43%
saiditworked well
30%
saidit'sa big hassle

Have you used Geodon (ziprasidone)?

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Side effects
The Trilafon (perphenazine) FDA package insert doesn’t have numbers about how common side effects are.
23possible side effects
  • Sleepiness
    31%
  • Movement problems
    31%
  • Headache
    18%
  • Dizziness
    16%
  • Nausea
    10%
  • Restlessness
    10%
  • Weakness
    6%
  • Abnormal vision
    6%
  • Diarrhea
    5%
  • Dry mouth
    5%
  • Vomiting
    5%
  • Anxiety
    5%
  • Accidental injury
    4%
  • Increased salivation
    4%
  • High blood pressure
    3%
  • Tongue swelling
    3%
  • Sore throat
    3%
  • Difficulty swallowing
    2%
  • Muscle pain
    2%
  • Loss of sensation
    2%
  • Speech disorder
    2%
  • Shortness of breath
    2%
  • Itchy, red skin
    2%
See more detailed side effects
Risks and risk factors
  • Higher risk of death
    • People age 65 or older with dementia and psychosis
  • Difficulty controlling movements
  • Higher risk for falls
  • Sleepiness
    • Drinking alcohol or taking narcotics
  • Higher risk of infection
See more detailed risks and warnings
  • Increased risk of death
    • Elderly patients with dementia
  • Suicidal thoughts or behavior
  • Heart problems
    • History of heart problems
    • Taking other drugs that also cause heart rhythm changes
    • Low potassium
    • Low magnesium
  • Neuroleptic malignant syndrome (NMS)
  • Abnormal and involuntary muscle movements
    • Taking Geodon (ziprasidone) in higher doses or for a long time
    • Elderly women
  • Dizziness and falls
    • Dehydration
    • Taking blood pressure medications
    • History of heart disease
See more detailed risks and warnings