Compare perphenazine vs. thioridazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Trilafon (perphenazine)

Prescription only

Mellaril (thioridazine)

Prescription only
Treats schizophrenia.

Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.

Treats schizophrenia.

Taking Mellaril (thioridazine) is one of many options to treat schizophrenia if other medicines haven't worked, but there are some side effects which can be dangerous.

Upsides
  • Trilafon (perphenazine) can be much cheaper than other medicines.
  • Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
  • Available in generic.
  • Compared to other similar medicines, Mellaril (thioridazine) is less likely to cause problems controlling your movements.
Downsides
  • You're more likely to gain weight.
  • You can be more sensitive to temperature changes.
  • You're more likely to catch colds and flu.
  • Mellaril (thioridazine) is only recommended for schizophrenia if other medicines haven't worked because the side effects can be very dangerous.
  • You have to take Mellaril (thioridazine) numerous times a day which can make it hard to remember.
  • Mellaril (thioridazine) can interfere with your heartbeat, so your doctor might have you do annual tests with your heart to make sure it's healthy.
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Reviews
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Side effects
The Trilafon (perphenazine) FDA package insert doesn’t have numbers about how common side effects are.
The Mellaril (thioridazine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Higher risk of death
    • People age 65 or older with dementia and psychosis
  • Difficulty controlling movements
  • Higher risk for falls
  • Sleepiness
    • Drinking alcohol or taking narcotics
  • Higher risk of infection
See more detailed risks and warnings
  • Problems with the heartbeat
    • History of heartbeat problems
    • Taking medicines for depression
    • Taking beta blockers
  • Increased risk of death in elderly people with dementia
    • People older than 65 years with dementia and psychosis
  • Difficulty controlling movements
    • Long-term use of Mellaril (thioridazine)
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Sleepiness and risk of falls
    • Drinking alcohol or taking narcotics
  • Decreased white blood cells
    • History of low white blood cells
See more detailed risks and warnings