Compare perphenazine vs. thiothixene

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Trilafon (perphenazine)

Prescription only

Navane (thiothixene)

Prescription only
Treats schizophrenia.

Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.

Treats schizophrenia.

Navane (thiothixene) isn't a first choice for treating schizophrenia because of the side effects, but it is cheaper than other medicines.

Upsides
  • Trilafon (perphenazine) can be much cheaper than other medicines.
  • Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
  • Navane (thiothixene) is available in generic.
  • Navane (thiothixene) is less likely to make you sleepy.
Downsides
  • You're more likely to gain weight.
  • You can be more sensitive to temperature changes.
  • You're more likely to catch colds and flu.
  • Side effects include weight gain and high blood sugar.
  • Navane (thiothixene) can cause low blood pressure, which can cause fainting or falls if you’re not careful.
  • Smoking tobacco can make Navane (thiothixene) work poorly.
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Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
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Side effects
The Trilafon (perphenazine) FDA package insert doesn’t have numbers about how common side effects are.
The Navane (thiothixene) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Higher risk of death
    • People age 65 or older with dementia and psychosis
  • Difficulty controlling movements
  • Higher risk for falls
  • Sleepiness
    • Drinking alcohol or taking narcotics
  • Higher risk of infection
See more detailed risks and warnings
  • Higher risk of death
    • People age 65 or older with dementia and psychosis
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
  • Drowsiness and sleepiness
    • Drinking alcohol, or taking opioids, benzodiazepines, or sleeping medicines
  • Low blood pressure
See more detailed risks and warnings