Compare Phenergan vs. Aloxi

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Phenergan (Promethazine)

Prescription only

Aloxi (palonosetron)

Prescription only
Helps you feel less queasy.

Phenergan (Promethazine) is used to treat and prevent nausea and vomiting from surgery, motion sickness, or pregnancy. While it's cheap and available in different forms to make it easier to take, it can make you feel very sleepy, and its side effects mean that children under 2 and adults over 65 shouldn't take it.

4.4/ 5 average rating with 38 reviewsforPhenergan
Stops nausea caused by chemotherapy or surgery.

Aloxi (palonosetron) is given one time to effectively reduce nausea from chemotherapy or surgery. In some cases, it will only help for a short period of time.

Upsides
  • Available in generic.
  • Available as a syrup or tablet that you can take by mouth, or as a rectal suppository if you're unable to take anything by mouth.
  • Aloxi (palonosetron) can be given through the same IV line as your chemotherapy - as a one-time dose 30 minutes before treatment starts.
  • Starts working in 30 minutes.
  • Aloxi (palonosetron) can be used in children as young as 1 month of age.
Downsides
  • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
  • Can't be used in children under 2 years of age or if you're over 65 because of increased risk from side effects.
  • Can make your skin more sensitive to the sun.
  • If your chemotherapy is very likely to make you feel queasy or if you have nausea after surgery, Aloxi (palonosetron) is usually only helpful for one day.
  • Can only be used to prevent nausea and vomiting, not to treat if it's already happening.
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Used for
  • Nausea and vomiting from chemotherapy or surgery
Dosage forms
  • Pill
  • Liquid
  • Suppository
  • Injection
Price
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Reviews
38 reviews so far
82%
saidit'sworth it
76%
saiditworked well
5%
saidit'sa big hassle

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Side effects
The Phenergan (Promethazine) FDA package insert doesn’t have numbers about how common side effects are.
4possible side effects
  • Abnormal heartbeat
    5%
  • Slow heart rate
    4%
  • Headache
    3%
  • Constipation
    2%
See more detailed side effects
Risks and risk factors
  • Slowing or stopping of breathing
    • Children under 2 years of age
  • Seizures
    • History of seizures
  • Sunburn
  • Involuntary muscle movements
    • Age over 65
  • Neuroleptic malignant syndrome
See more detailed risks and warnings
  • Serotonin syndrome
    • Taking antidepressants, lithium, some migraine medications, and St. John's wort.
  • Severe allergic reaction
See more detailed risks and warnings