Compare Phenergan vs. Anzemet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Phenergan (Promethazine)

Prescription only

Anzemet (dolasetron)

Prescription only
Helps you feel less queasy.

Phenergan (Promethazine) is used to treat and prevent nausea and vomiting from surgery, motion sickness, or pregnancy. While it's cheap and available in different forms to make it easier to take, it can make you feel very sleepy, and its side effects mean that children under 2 and adults over 65 shouldn't take it.

4.4/ 5 average rating with 38 reviewsforPhenergan
Helps prevent nausea and vomiting

Anzemet (dolasetron) prevents nausea and vomiting and does not have many side effects.

Upsides
  • Available in generic.
  • Available as a syrup or tablet that you can take by mouth, or as a rectal suppository if you're unable to take anything by mouth.
  • Reduced nausea and vomiting in people receiving chemotherapy.
  • Well-tolerated with mild headache as the most common side effect.
  • Requires only 1 dose prior to chemotherapy and once daily dosing after chemotherapy if needed for delayed nausea/vomiting.
Downsides
  • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
  • Can't be used in children under 2 years of age or if you're over 65 because of increased risk from side effects.
  • Can make your skin more sensitive to the sun.
  • Anzemet (dolasetron) doesn't treat nausea and vomiting that's already happening. It only works to prevent future episodes.
  • High doses of Anzemet (dolasetron) can cause problems with heart rhythm.
  • Can be expensive since a generic version is not available.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Suppository
  • Pill
Price
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Reviews
38 reviews so far
82%
saidit'sworth it
76%
saiditworked well
5%
saidit'sa big hassle

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Side effects
The Phenergan (Promethazine) FDA package insert doesn’t have numbers about how common side effects are.
9possible side effects
  • Headache
    23%
  • Fatigue
    6%
  • Diarrhea
    5%
  • Decreased heart rate
    4%
  • Dizziness
    3%
  • Pain
    3%
  • Increased heart rate
    3%
  • Indigestion
    2%
  • Chills/shivering
    2%
See more detailed side effects
Risks and risk factors
  • Slowing or stopping of breathing
    • Children under 2 years of age
  • Seizures
    • History of seizures
  • Sunburn
  • Involuntary muscle movements
    • Age over 65
  • Neuroleptic malignant syndrome
See more detailed risks and warnings
  • Abnormal heart rhythm
    • History of heart rhythms such as long QT syndrome or atrial fibrillation
    • Heart failure
    • Taking other medications that can affect heart rhythms
    • Low potassium or magnesium levels
    • Advanced age
  • Serotonin syndrome
    • Taking other medicines that affect serotonin levels such as tramadol and anti-depressants
See more detailed risks and warnings